临床荟萃 ›› 2024, Vol. 39 ›› Issue (12): 1115-1118.doi: 10.3969/j.issn.1004-583X.2024.12.010

• 论著 • 上一篇    下一篇

复方甘草片致低血钾伴横纹肌溶解1例并文献复习

刘颖柔1, 宋慧2(), 李冠江2, 张秀刚2   

  1. 1.河北医科大学附属沧州市中心医院 消化内科,河北 沧州 061000
    2.沧州市中心医院 消化内科,河北 沧州 061000
  • 收稿日期:2024-05-16 出版日期:2024-12-20 发布日期:2025-01-10
  • 通讯作者: 宋慧,Email: alahui2004@126.com

Treatment of hypokalemia and rhabdomyolysis caused by compound liquorice tablets: A case report and literature review

Liu Yingrou1, Song Hui2(), Li Guanjiang2, Zhang Xiugang2   

  1. 1. Department of Gastroenterology,Cangzhou Central Hospital Affiliated to Hebei Medical University, Cangzhou 061000,China
    2. Department of Gastroenterology,Cangzhou Central Hospital,Cangzhou 061000,China
  • Received:2024-05-16 Online:2024-12-20 Published:2025-01-10
  • Contact: Song Hui,Email: alahui2004@126.com

摘要:

目的 探讨复方甘草片所致低血钾伴横纹肌溶解的有效治疗手段。方法 回顾性分析1例复方甘草片治疗干咳致低血钾伴横纹肌溶解患者的临床诊疗经过,并复习相关文献。结果 患者为71岁男性,主因食欲不振伴四肢麻木7 d入院治疗,入院后追问病史并完善化验检查,考虑复方甘草片导致重度低钾血症导致横纹肌溶解及代谢性碱中毒,停用复方甘草片并予补钾补液等治疗后,低钾血症纠正,肌酶水平逐渐恢复正常,预后良好。结论 低血钾伴横纹肌溶解是甘草制剂的不良反应,可诱发急性肾功能衰竭及多脏器功能衰竭,严重者可导致死亡,早期发现,早期干预,一般预后良好。

关键词: 低钾血症, 横纹肌溶解, 复方甘草片

Abstract:

Objective To explore the effective treatment of hypokalemia combined with rhabdomyolysis caused by compound liquorice tablets. Methods The clinical diagnosis and treatment of 1 case of hypokalemia combined with rhabdomyolysis caused by compound liquorice tablets for treating dry cough was retrospectively analyzed, and the relevant literature was reviewed. Results A 71-year male presented for 7 days of anorexia and numbness of limbs. After admission, the medical history was inquired and laboratory tests were performed. He was diagnosed as severe hypokalemia combined with rhabdomyolysis and metabolic alkalosis caused by compound liquorice tablets. After withdrawal of the compound licorice tablets, potassium infusion and fluid replacement, the hypokalemia was corrected, and the muscle enzyme level gradually returned to normal with a good prognosis. Conclusion Hypokalemia combined with rhabdomyolysis is an adverse event of using licorice preparations, leading to acute renal failure, multi-organ dysfunction syndrome or even death. Early detection and intervention generally result in a favorable prognosis.

Key words: hypokalemia, rhabdomyolysis, compound liquorice tablets

中图分类号: