Abstract: Objective  To analyze the difference  between central arterial blood pressure and brachial blood pressure, and to evaluate the influencing factors of the difference between peripheral blood pressure and central arterial blood pressure in middleaged and elderly patients with coronary artery disease. Methods  Patients with cardiovascular disease and undergoing coronary arteriography were selected from May, 2018 to April, 2019.According to whether there were clinical symptoms of cardiac insufficiency, the patients were divided into experimental group (51 cases) and control group (66 cases). The data of patients in two groups were recorded, including gender, age, body mass index (BMI), LVEF,NTproBNP, creatinine, glycosylated hemoglobin and blood lipids. The cSBP, cDBP were recorded in the period of coronary arteriography, and SBP and DBP value of brachial were measured at the same time.    Genaini integral method was used to evaluate the degree of coronary artery lesions and range. Results  The LVEF value  in experimental group was lower than that in control group (P<0.05). There were significant differences in cSBP, cDBP, △SBP (△SBP =SBPcSBP),△DBP (△DBP= DBPcDBP) and Genaini integral between two groups(P＜0.05). Genaini integral was a risk factor of △ BP＜10(P＜0.01，OR=28.836). Conclusion   Monitoring of difference between central artery and brachial artery blood pressure may provide reference for evaluating the degree of coronary artery lesions.

Key words: hypertension,  , coronary disease, central venous pressure, heart function tests, aged