Association study between single nucleotide polymorphisms of interleukin 23 receptor and rheumatoid arthritis

doi:10.3969/j.issn.1004-583X.2016.01.010

Abstract

Abstract: Objective To analyze the association between single nucleotide polymorphisms (SNPs) of interleukin 23 receptor (IL23R) and rheumatoid arthritis (RA).Methods Case-control study was performed on 228 RA cases and 228 controls. Tag-SNPs in IL23R gene were selected from the HapMap database Chinese population. A total of 14 tag-SNPs was examined by matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS).Results Significant differences were detected for three SNPs (rs10489628, rs10889675 and rs10889677) in genotype analysis between RA patients and healthy controls. No significant differences in the distribution of the haplotype were found.Conclusion This study suggests that IL23R is the susceptible gene for RA.

Key words: arthritis, rheumatoid, polymorphisms, single nucleotide, receptor,interleukin 23, association

CLC Number:

R593.22

Xie Qingyun, Wei Meng, Fu Peiliang, Sun Jiuyi, Qian Qirong. Association study between single nucleotide polymorphisms of interleukin 23 receptor and rheumatoid arthritis[J]. Clinical Focus, 2016, 31(1): 40-44.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2016.01.010

https://huicui.hebmu.edu.cn/EN/Y2016/V31/I1/40

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