Abstract:

Objective To investigate the difference between remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome and seronegative rheumatoid arthritis (SNRA). Methods During January 2009 to December 2020, a total of 12 patients with RS3PE syndrome (RS3PE group) admitted in our hospital were enrolled, and 36 patients with SNRA (SNRA group) during the same period were collected. In-group general data, clinical features and laboratory indexes were included as comparison. Results Compared with the SNRA group, the patients in the RS3PE group had older aged, more males, higher serum C-reactive protein (CRP), more involved in ankle joints, less involved in small joints and hand joints, and easy to combine tumor (all P<0.05). Conclusion Older men and relatively higher CRP levels are higher risk for combined tumors in patients with RS3PE syndrome, they are more likely to involve the ankle joint. A actively screened for malignancy should be carried out in older, male, and RS3PE syndrome patients with limb edema.

Key words: arthritis,rheumatoid, synovitis, inflammation