Abstract: Objective  To compare the neutrophil to lymphocyte ratio(NLR) and NGAL for  contrastinduced nephropathy(CIN) predictive value in patients with type 2 diabetes mellitus. Methods  A total of 88 patients with enhanced CT of type 2 diabetes mellitus were selected. The blood routine examination,  SCr，CysC, hsCRP and NGAL were measured before enhanced CT,  after 6 hours,  24 hours and  48 hours of enhanced CT. According to the results of  tourine MA/Cr, the patients were divided into two groups, diabetic nephropathy(DN) and non DN group. Based on the diagnosis of CIN, the 88 patients were divided into CIN group(n=82) and normal group(n=6)  to analyze the association of  NLR  and NGAL,  and to compare the predictive value of NLR and other indexes.Results  Totally six patients (6.8%) with DN suffered from CIN after enhanced CT. NLR and NGAL were higher in patients with DN than patients without DN（P＜0.05）. Pearson correlation analysis showed that NLR was positively associated with SCr（r=0.785，P=0.012） and NGAL （r=0.764，P=0.018）. After adjustment for some factors,  according to the logistics regression, NLR  was still a  risk factor of CIN（P＜0.05）.Conclusion  DN patients are more likely to have CIN.  NLR  and urine NGAL were higher in patients with DN.

Key words: inflammation；diabetes mellitus；nephrosis, contrast media