Abstract: ObjectiveTo evaluate the diagnostic value of endobronchial ultrasound transbronchial lung biopsy with guidesheath (EBUSGS) in benign peripheral pulmonary lesions（PPL）．MethodsRetrospective analysis was performed in 49 patients with PPL inaccessible by conventional bronchoscopy．The diagnostic yield，safety and associated factors were analyzed．ResultsFortynine patients with PPL (35 males and 14 females，age  35 to 88 years，mean ［63.1±11.1］ years) were confirmed by CT but not detected by conventional bronchoscopy．PPL were examined in 49 patients，and 37 cases with PPL were detected by EBUSGS，and the diagnostic rate was 75.5%．The diagnosis rate of malignant PPL was 87.5% (14/16)， while that of benign disease was 69.7％(23/33)．All patients tolerated the procedure very well．Mild bleeding was observed in the biopsies of some patients．No pneumothorax or other serious complications were observed.ConclusionThe technique of EBUSGS was safe，and its diagnostic rate was higher to either malignant or benign PPL.

Key words: lung diseases；bronchoscopy, endosonography, biopsy, needle