Abstract: Peripheral pulmonary lesions (PPL) is very common in clinical work， and the diagnosis of PPL is a challenging task for pulmonologists. PPL includes a variety of diseases with similar Xray findings， such as bronchial lung cancer， lung metastases， tuberculosis and so on. Diagnostic yield of routine bronchoscopy in PPL is very low， and CT guided percutaneous cutting needle lung biopsy may result in more complications in the lesions far from the chest wall. Multiple approaches may be undertaken to establish a tissue diagnosis， including thin (or) ultrathin bronchoscopy， transbronchial lung biopsy， endobronchial ultrasound transbronchial lung biopsy with guidesheath，bronchoalveolar lavage and bronchoscopic navigation system. A suitable method or combination of two methods matter much to improve the diagnostic the accuracy of PPL.

Key words: lung diseases；bronchoscopy, ultrasonography, interventional, biopsy