Abstract: Objective  To investigate the efficacy of selective intracoronary thrombolysis combined with interventional therapy and direct intracoronary intervention on acute ST segment elevation myocardial infarction(STEMI). Methods  From October 2018 to October 2019, a total of 61 STEMI patients admitted to Gongyi People's Hospital were divided into control group (direct PCI, n=31) and treatment group (thrombolysis + PCI, n=30) by a randomized and singleblind method. TIMI blood flow grading, Nterminal proBtype natriuretic peptide (NTProBNP) level, left ventricular ejection fraction (LVEF) value, mortality during hospitalization, reinfarction rate and incidence of bleeding events were observed in two groups. Results  After treatment, the TIMI blood flow grading　in treatment group was better than that of control group (P<0.05). Conclusion  Compared with direct intracoronary thrombolysis, interventional therapy after intracoronary thrombolysis can better improve the myocardial perfusion level in patients, reduce the incidence of noreflow, improve cardiac function and not increase the incidence of bleeding during hospitalization.

Key words: myocardial infarction;urinary plasminogen activator, coronary artery, thrombolysis, radiology, , interventional