Abstract: ObjectiveTo observe the control of wound infection， drug resistance and wound healing in topical antibiotics combined with systemic antibiotics therapy for treating diabetic foot infection(DFI). MethodsOne hundred and ten hospitallized patients with DFI in our hospital were selected， then the patients were randomly divided into two subgroups， control group and observation group，each group 55 cases. According to anklebrachial index，each group was divided into two subgroups， nonischemic group and ischemia group.All patients accepted norms of diabetic foot infection therapy， patients in experimental group using moxifloxacin hydrochloride's absorbability gelatin sponge treatment. At days of 0，14，28， blood samples were collected to test infectionrelated indicators， bacterial culture and sensitivity test， measuring of wound area and calculate the total efficiency.ResultsAt 14 and 28 days， the infectionrelated indicators in observation group were decreased，wounds size reduction and total clinical efficiency were better than those of control group(P＜0.05). Antibiotic bacterial resistance were not increased(P>0.05); For ischemia group in observation group，the infectionrelated indicators were decreased， wounds size reduction and total clinical efficiency were better than those of control group (P＜0.05)，but in the nonischemic group， they showed no significant  difference(P>0.05).ConclusionTopical application seems safe，can control  infection and promote wound healing when combined with systemic antibiotics  therapy in DFI patients with ischemia.

Key words: diabetic foot, infection , antibacterial agents, moxifloxacin hydrochloride