Abstract: Objective  To explore the relationships between neutropiltolymphocyte ratio (NLR)， platelettolymphocyte ratio (PLR) and disease activity in Sjogren's syndrome (SS). Methods  Clinical data of sixtytwo patients with SS and fiftyone healthy controls were collected. NLR and PLR were calculated and compared between two groups through nonparametric test. Correlation among NLR， PLR and other data in SS patients were analyzed by pearson correlation and multiple linear regression. EULAR SS disease activity index (ESSDAI) was used to assess disease activity. The ROC curve was drawn to evaluate whether NLR or PLR could reflect disease activity in SS. Results   In SS patients， NLR and PLR levels were higher than those of healthy controls. Both NLR and PLR were positively correlated with globulin， IgG， IgA， RF and negatively correlated with total cholesterol (TC) and low density lipoprotein cholesterol (LDLC). NLR was positively correlated with PLR as well. Multiple linear regression analysis showed NLR was correlated with PLR， TC and LDLC， while PLR was correlated with NLR， globulin， IgG and TC. The ROC curve showed PLR could reflect disease activity with higher specificity. Conclusion  NLR and PLR were correlated with SS severity and may be helpful in assessing  the  disease activity.

Key words: Sjogren’s syndrome, granulocytes, lymphocytes, blood , platelets