Abstract: Objective  To investigate the use of antibiotics,  the distribution of common infection sites and pathogens and their drug resistance in elderly inpatients in geriatric wards,  and to provide reference for clinical antiinfective therapy in elderly patients. Methods  A retrospective analysis was conducted on the of discharged geriatric patients from January 2015 to December 2017, including 306 cases using antibiotics. The susceptibility test of the isolated strain was carried out by disk expansion method (KB),  and the results were judged according to the clsi100 standard.The results were judged according to CLSI100 standard. Results  The monthly antibiotic use rate was 37.74%  in January and 26.56% in December, which was significantly higher than those in other months (P<0.05).The total number of isolated strains was 254. Gramnegative(G-) bacteria accounted for 53.54%,  Grampositive(G+)  bacteria 34.65%, and fungi 11.81%. Pseudomonas aeruginosa, Escherichia coli are highly sensitive to piperacillin,  etapenem and imipenem.No resistance to linazolamine, vancomycin and rifampicin were found in these G+ strains.Conclusion  January and December are highincidence season for infection in the elderly, and community and hospital should make full preparation to prevent it. G- bacteria infection is  still the most common one  in the elderly. Clinically speaking, it is necessary to culture bacteria as early as possible and select sensitive antibiotics.

Key words: antibiotics, microbial sensitivity tests, elderly