Abstract: Objective  To investigate the pathogenic bacteria distribution and drug sensitivity of blood stream infection in patients  and provide basis for clinical treatment of blood stream infection. Methods  Strains and clinical data of patients with blood stream infection from June 2015 to April 2018 were collected.Strains identification and susceptibility tests were performed using vitek2 compact. Anaerobic bacteria were detected by concentration gradient method.Results  A total of 1 113 strains of pathogens were isolated from 1 101 patients. 24 patients were treated with mix bacteremia.There were 576 (51.75%) strains of gramnegative bacteria, 510 (45.82%) strains of grampositive bacteria, 27 (2.43%)  strains of fungi and 72 strains of Anaerobic bacteria were isolated. The first seven departments of the distribution of pathogenic bacteria are hematology,  infectious diseases,  geriatrics,  neonatology,  pediatric medicine,  oncology and critical care.The strains of Escherichia coli and Klebsiella pneumoniae have high antibacterial activity against piperacillin/tazobactam,  cefoperazone/sulbactam,  amikacin and tegacycline.The detection rates of MRSA and MRCNS were 27.8% and 82.2% respectively. All Staphylococci were sensitive to vancomycin and linezolid. All enterococci were sensitive to glycopeptides and oxazolidinone antibiotics. Anaerobic bacteria produce an average of 44.4% of the β lactamase. The rate of fragile bacteroides is Highest(87.5%).Conclusion  The characteristics of strains from bloodstream were different. The area should be alert to brucella and methicillin resistant Staphylococcus  infection; Clinical laboratories should not overlook anaerobic and lowtoxic species such as nontuberculosis mycobacteria and nocardia in bloodstream.

Key words: infection, pathogenic bacteria, antibacterial agents, drug resistance