Urine UbA52 and urine VDBP detection and significance in patients with diabetic nephropathy

doi:10.3969/j.issn.1004-583X.2019.06.011

Abstract

Abstract: Objective To explore the value of urine ubiquitin 52 amino acid fusion protein(UbA52) and urine vitamin D binding protein(VDBP) in diabetic nephropathy(DN) diagnosis by detecting urine UbA52 and urine VDBP concentrations.Methods A total of 46 patients with DN and 38 patients with type 2 diabetes mellitus were treated as DN group and diabetic group.ELISA was used to detect UbA52 and VDBP in urine. Analysis of differences between three groups, the differences on DN diagnostic specificity and sensitivity in urine UbA52 and urine VDBP, urinary protein quantitative and urinary creatinine ratio (ACR) were compared.Results Urine UbA52 and urine VDBP of three groups were significantly different from each other(P＜0.05). Urine UbA52 and urine VDBP of DN group were significantly higher than those of diabetes group and normal control group.Urine UbA52 and urine VDBP of DN group and normal control group were not significantly different (P＞0.05). The area under the ROC curve of urine UbA52, urine VDBP，24hour urine protein quantification，ACR，urine UbA52 combined urine VDBP in diagnosis of DN were 0.729, 0.776，0.629, 0.657，0.779，respectively.Conclusion The detection of urine UbA52 and urine VDBP levels have certain reference value in evaluating the condition of DN. The combined detection of urine UbA52 and urine VDBP has important clinical significance in diagnosis of DN.

Key words: diabetic nephropathies, ubiquitins, vitamin D binding protein; , diagnosis

Wang Jiangli1, Liu Maodong2, Chi Yanqing2, Zhang Yimin3, Li Ying2. Urine UbA52 and urine VDBP detection and significance in patients with diabetic nephropathy[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2019.06.011.

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https://huicui.hebmu.edu.cn/EN/Y2019/V34/I6/541

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Urine UbA52 and urine VDBP detection and significance in patients with diabetic nephropathy

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