Abstract: Objective  To evaluate the efficacy and safety of steroid combined with thalidomide in the treatment of connective tissue disease with interstitial lung fibrosis (CTDILD). Methods  Sixtysix patients were randomly divided into two groups:  control group was given prednisone acetate  and other routine treatment. The combined group took thalidomide  more,  and the course of treatment was six months. Results   The clinical symptoms,  pulmonary function and pulmonary CT improvement in combined group were better than those in control group (P<0.05). In the course of treatment,  there was no significant difference in the incidence of adverse reactions between  two groups (P>0.05). Conclusion  Thalidomide in the treatment of CTDILD can improve the therapeutic effect and has no obvious adverse reactions.

Key words: mixed connective tissue disease;lung disease, , interstitial;drug therapy, , combination