Abstract: Objective  To investigate the characteristics of intestinal flora in hyperuricemia (HUA) patients, and to explore the effects of bifidobacterium quadruple bacteria on HUA and itsmicroflora changes.Methods  A total of 100 HUA patients were enrolled and randomly divided into experimental group (group A) and standard group (group B), with 50 cases in each group. And  50 healthy volunteers were selected as the control group (group C).The baseline characteristics of each group were similar. Group A and B were given febuxostat tablets as routine therapeutic strategies for 2 weeks, while group Bwas also given bifidobacterium quadruple bacteria tablets. The blood uric acid levels and faeces in each group were detected before and after treatment.Results  The contents of bifidobacterium,  lactobacillus and enterococcus faecalis in feces of HUA groups were remarkably lower than those in control group, while the escherichia coli levels were significantly higher(P<0.05).  The blooduric acid levels in both group A and B substantially decreased after treatment, and a greater decline was observed in group A (P<0.05).The amount of uric acid decomposed by bacteria in faeces of group A was statistically higher than that before treatment. There was statistically significant difference in the amount of uric acid between group A and B (P<0.05). The amounts of bifidobacterium, lactobacillus and enterococcus faecalis in faeces of group A were greatly higher than before. Compared with the amount of group B, there was statistically significant difference (P<0.05).Conclusion  The adjuvant therapy of bifidobacterium quadruple bacteria  for the treatment of HUA patients can significantly reduce blooduric acid level, which may be related to the enhancement of intestinal bacterial uric acid decomposition.

Key words: bifidobacterium quadruple bacteria tablet, hyperuricemia, enterobacteriaceae