Correlation analysis of serum uric acid, creatinine and cystatin C levels with  neurological deficits in young stroke patients

doi:10.3969/j.issn.1004-583X.2020.07.007

Abstract

Abstract: Objective To analyze the correlation between serum uric acid (SUA), creatinine (Cr) and cystatin C (CysC) levels and the degree of neurological deficits in young stroke patients. Methods Forty young patients with stroke who were hospitalized in Department of Neurology of Beijing Pinggu Hospital from May 2019 to December 2019 were selected as study group, and 40 healthy people who received physical examinations in the hospital were selected as control group during the same period. The levels of SUA, Cr, and CysC in two groups were compared by retrospective analysis of the clinical data.And at the same time, patients were divided into mild group, moderate group, and severe group according to National Institute of Health Stroke Scale(NIHSS). SUA, Cr, and CysC in patients with different NIHSS scores were compared.The correlation between SUA, Cr, CysC and NIHSS scores were analyzed by linear regression. Results The levels of SUA, Cr and CysC in study group were significantly higher than those in control group (P<0.05); SUA, Cr and CysC of patients with different degrees of neurological deficits were different(P<0.05). With the aggravation of neurological deficits, the levels of SUA, Cr and CysC in patients also gradually increased. The results of correlation analysis showed that SUA, Cr and CysC of young stroke patients were significantly positively correlated with NIHSS scores (r=0.954, 0.954, 0.953, P<0.01). Multiple linear regression results showed that SUA, Cr, and CysC were all independent influencing factors of NIHSS score in young stroke patients (P<0.05). Conclusion The levels of SUA, Cr, and CysC in young stroke patients are significantly positively correlated with NIHSS scores, and SUA, Cr, and CysC are independent influencing factors of NIHSS score in young stroke patients. By detecting the levels of SUA, Cr and CysC in young stroke patients, the early prediction of the degree of neurological deficits in patients can be realized.

Key words: uric acid, creatinine, cystatin C, stroke, neurological deficit

Yu Honga, Li Jiayana, Fu Yananb. Correlation analysis of serum uric acid, creatinine and cystatin C levels with neurological deficits in young stroke patients[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2020.07.007.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2020.07.007

https://huicui.hebmu.edu.cn/EN/Y2020/V35/I7/616

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Correlation analysis of serum uric acid, creatinine and cystatin C levels with neurological deficits in young stroke patients

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