Relationship between eosinophil levels and carotid atherosclerosis in maintenance hemodialysis patients

doi:10.3969/j.issn.1004-583X.2021.01.009

Abstract

Abstract:

Objective To investigate the relationship between eosinophil (EOS) level and carotid atherosclerosis in maintenance hemodialysis (MHD) patients. Methods 151 MHD patients with complete clinical data in our hospital were selected and divided into control group and hardening group 96 cases according to carotid ultrasound. Comparison of two groups included high sensitivity C-reactive protein (hs-CRP), eosinophil (EOS), white blood cell (WBC), hemoglobin (HB), platelet (PLT), albumin (ALB), serum ferritin (SF), intact parathyroid hormone (iPTH), total cholesterol (TC), low density lipoprotein (LDL-C), triglyceride (TG), high-density lipoprotein (HDL-C), small and low-density lipoprotein (sdLDL), lipoprotein a (Lpa). The patients were divided into the lower quartile group, the middle quartile group, and the upper quartile group according to the quartiles of EOS. The detection rates of carotid atherosclerosis and micro-inflammation were compared among the three groups, and the relationship between eosinophil level and carotid atherosclerosis was analyzed.The correlation between carotid intima-media thickness (IMT) and EOS count was analyzed. Observation was further performed for the role of EOS in carotid atherosclerosis in MHD patients.Results Among 151 patients, 96 patients (64%) had carotid atherosclerosis. The number of patients with microinflammation in sclerotic group was more than that in control group, and TC, LDL-C, sdLDL levels were higher in sclerotic group(P<0.05); There were significant differences in the detection rate of carotid atherosclerosis and microinflammation among different EOS groups (P<0.05); IMT was positively correlated with EOS, TC, LDL-C.TC and LDL-C are independent factors of cervical arteriosclerosis in MHD patients. Conclusion Eosinophilia is a related factor of carotid atherosclerosis in MHD(maintenance hemodialysis) patients, and MHD patients with higher eosinophilia level are more likely to develop carotid atherosclerosis.

Key words: renal dialysis, eosinophils, carotid atherosclerosis

CLC Number:

R459.5

Shang Qihang, Chen Huaqian. Relationship between eosinophil levels and carotid atherosclerosis in maintenance hemodialysis patients[J]. Clinical Focus, 2021, 36(1): 44-48.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2021.01.009

https://huicui.hebmu.edu.cn/EN/Y2021/V36/I1/44

Figures/Tables 4

References 25

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组别	例数	EOS (×10⁹/L)	WBC (×10⁹/L)	HB (g/L)	PLT (×10⁹/L)	ALB (g/L)	SF (μg/L)	iPTH (pg/ml)
对照组	55	0.16±0.13	6.70±2.15	106.41±21.36	167.49±62.29	37.90±4.59	389.50(193.10,602.30)	201.20(102.60,286.80)
硬化组	96	0.30±0.39	6.30±2.29	106.93±18.72	173.34±66.52	38.84±5.59	370.05(157.80,716.95)	182.40(99.45,314.15)
t/Z值		-5.019	0.992	0.031	-0.306	-1.011	-0.337	0.609
P值		0.028	0.323	0.975	0.760	0.314	0.737	0.544
组别	例数	TC (mmol/L)	TG (mmol/L)	LDL-C (mmol/L)	HDL-C (mmol/L)	sdLDL (mmol/L)	Lpa (mg/L)	微炎症状态(例)
对照组	55	2.99±0.81	1.50±1.33	1.42±0.65	0.85(0.65,1.02)	0.30(0.19,0.49)	161.00(90.00,239.00)	15
硬化组	96	4.17±1.20	1.49±0.87	2.37±0.94	0.91(0.72,1.10)	0.42(0.30,0.78)	171.00(81.00,288.50)	39
t/χ²/Z值		-6.230	0.083	-6.346	-0.118	-2.208	-0.258	4.505
P值		0.000	0.787	0.000	0.329	0.029	0.421	0.034

组别	例数	EOS (×10⁹/L)	WBC (×10⁹/L)	HB (g/L)	PLT (×10⁹/L)	ALB (g/L)	SF (μg/L)	iPTH (pg/ml)
对照组	55	0.16±0.13	6.70±2.15	106.41±21.36	167.49±62.29	37.90±4.59	389.50(193.10,602.30)	201.20(102.60,286.80)
硬化组	96	0.30±0.39	6.30±2.29	106.93±18.72	173.34±66.52	38.84±5.59	370.05(157.80,716.95)	182.40(99.45,314.15)
t/Z值		-5.019	0.992	0.031	-0.306	-1.011	-0.337	0.609
P值		0.028	0.323	0.975	0.760	0.314	0.737	0.544
组别	例数	TC (mmol/L)	TG (mmol/L)	LDL-C (mmol/L)	HDL-C (mmol/L)	sdLDL (mmol/L)	Lpa (mg/L)	微炎症状态(例)
对照组	55	2.99±0.81	1.50±1.33	1.42±0.65	0.85(0.65,1.02)	0.30(0.19,0.49)	161.00(90.00,239.00)	15
硬化组	96	4.17±1.20	1.49±0.87	2.37±0.94	0.91(0.72,1.10)	0.42(0.30,0.78)	171.00(81.00,288.50)	39
t/χ²/Z值		-6.230	0.083	-6.346	-0.118	-2.208	-0.258	4.505
P值		0.000	0.787	0.000	0.329	0.029	0.421	0.034

EOS分组	例数	颈动脉粥样硬化	微炎症状态
低	44	21(47.7)	10(22.7)
中	69	42(60.8)	23(33.3)
高	38	29(76.3)	20(52.6)
χ²值		7.001	7.103
P值		0.030	0.029

EOS分组	例数	颈动脉粥样硬化	微炎症状态
低	44	21(47.7)	10(22.7)
中	69	42(60.8)	23(33.3)
高	38	29(76.3)	20(52.6)
χ²值		7.001	7.103
P值		0.030	0.029

指标	IMT
指标	r值	P值
EOS	0.212	0.009
WBC	0.002	0.976
PLT	0.060	0.462
HB	-0.007	0.927
ALB	0.063	0.439
iPTH	-0.070	0.414
SF	0.014	0.872
TC	0.320	0.000
TG	0.143	0.080
LDL-C	0.310	0.000
HDL-C	0.069	0.402
dsLDL	0.171	0.052
Lpa	0.035	0.710