Abstract: Objective  To compare the effects of different hemopurification modes on beta 2microglobulin (β2MG) and calciumphosphorous metabolism with maintenance hemodialysis(HD) patients. Methods  Totally 84 maintenance hemodialysis patients were enrolled and randomed into three groups. Group HD was treated by lowflux HD three times a week. Group HD+ hemodialysis filtration (HD+HDF) was treated by lowflux hemodialysis two times a week + hemodiafiltration one time a week. Group highflux HD (HFHD) was treated by HFHD three times a week. All patients were followed up for six months. Calcium， phosphorous， Ca×P product， intact parathyroid hormone (iPTH) and β2MG were measured before and after six months’  treatment. Results  The levels of serum phosphorus， Ca×P product， iPTH and β2MG in group HD showed no  significant decrease before and after treatment (P>0.05). Serum phosphorus， Ca×P product， iPTH and β2MG in group HD+HDF and HFHD decreased significantly before and after treatment as compared with those in group HD， respectively (P<0.05). Serum phosphorus in group HFHD reduced more than that in group HD+HDF (P<0.05). The levels of Ca×P product， iPTH， β2MG had no significant difference between HFHD and HD+HDF group (P>0.05). Conclusion  Both HFHD and HD+HDF could significantly reduce serum phosphorus， Ca×P product， iPTH and β2MG， and also effectively improve the calcium and phosphorus metabolism in MHD patients. HFHD might be a better hemopurification mode due to the advantages of convenient operation and low cost.

Key words: renal dialysis, beta 2microglobulin;calcium, phosphorus