Abstract:

Objective To investigate clinical changes and value of vascular endothelial growth factor(VEGF), intercellular adhesion molecule-1(ICAM-1), interleukin-13(IL-13), fractionated exhaled nitric oxide(FeNO) level of induced sputum on asthma, asthma-copd overlap syndrome(ACO), and chronic obstructive pulmonary disease(COPD) in patients. Methods Totally 77 asthma patients (asthma group), 78 COPD patients (COPD group) and 80 ACO patients (ACO group) were selected in our hospital from Jun 2018 to Jun 2020, general data, lung function indicators and levels of VEGF, ICAM-1, IL-13, FeNO were obtained among the three groups. Results Among the three groups, age in COPD group was the oldest, in descending order: COPD group >ACO group >asthma group (allP<0.05); smoking history in ACO group was highest, in descending order: asthma group >ACO group >COPD group (P<0.05); proportion of patients with family history of smoking in asthma group and ACO group were increased generally (all P<0.05). FEV1, FEV1/FVC, FEV1/pre% in ACO group and COPD group were significantly lower than those in asthma group, but incidence of small airway dysfunction, RV/TLC were higher than those in asthma group(P<0.05); there were no statistically significant differences in above indicators between ACO group and COPD group (all P>0.05). VEGF and ICAM-1 in ACO group, asthma group were higher than those in COPD group, VEGF in ACO group was higher than that in asthma group(P<0.05). IL-13, FeNO in asthma group were hither than those in ACO group and COPD group, FeNO in ACO group was higher than that in COPD group (all P<0.05). Conclusion Levels of VEGF, ICAM-1,IL-13, FeNO are significantly different among asthma, ACO and COPD in patients, which has certain reference for clinic.

Key words: asthma, pulmonary disease, chronic obstructive, inflammatory factors, lung function, diagnosis, biochemical indicators