Clinical Focus ›› 2021, Vol. 36 ›› Issue (9): 843-849.doi: 10.3969/j.issn.1004-583X.2021.09.016
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Received:2021-05-05Online:2021-09-20Published:2021-10-05
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| 疾病类型 | 相关通路 | ceRNA | 靶基因 | 生物学功能 |
|---|---|---|---|---|
| AS | APJ/PKCa JAK2/STAT3 | MALAT1 MEG3 | LPL Sirt1 SOCS3 SH2B1 ABCA1 | 参与糖、脂质代谢、细胞增殖转移,抑制炎症因子 |
| AMI | 未知 | MEG3 | PHB1 VEGF BCL2/BAX p53 | 参与血管生成、细胞增殖转移、抑制凋亡,影响线粒体功能 |
| HA HHT CCM | TGFβ/BMP | NEAT1 | VEGFA IGF1 RAC1 CCM2 | 参与血管生成、细胞增殖转移、细胞外基质降解 |
| PAH | JAK/STAT3 | 未知 | SERT VEGF ABCA1 | 参与血管重塑、脂质代谢、细胞增殖转移 |
| VTE | TGFβ1/2 | 未知 | FGF1 | 参与血管生成、细胞增殖转移 |
| SSH | 未知 | OTX1-7:1 | PRKCA | 参与钙信号、血管平滑肌收缩、钠重吸收,调控钠离子转运体 |
| 疾病类型 | 相关通路 | ceRNA | 靶基因 | 生物学功能 |
|---|---|---|---|---|
| AS | APJ/PKCa JAK2/STAT3 | MALAT1 MEG3 | LPL Sirt1 SOCS3 SH2B1 ABCA1 | 参与糖、脂质代谢、细胞增殖转移,抑制炎症因子 |
| AMI | 未知 | MEG3 | PHB1 VEGF BCL2/BAX p53 | 参与血管生成、细胞增殖转移、抑制凋亡,影响线粒体功能 |
| HA HHT CCM | TGFβ/BMP | NEAT1 | VEGFA IGF1 RAC1 CCM2 | 参与血管生成、细胞增殖转移、细胞外基质降解 |
| PAH | JAK/STAT3 | 未知 | SERT VEGF ABCA1 | 参与血管重塑、脂质代谢、细胞增殖转移 |
| VTE | TGFβ1/2 | 未知 | FGF1 | 参与血管生成、细胞增殖转移 |
| SSH | 未知 | OTX1-7:1 | PRKCA | 参与钙信号、血管平滑肌收缩、钠重吸收,调控钠离子转运体 |
| [1] |
Grisar JC, Haddad F, Gomari FA, et al. Endothelial progenitor cells in cardiovascular disease and chronic inflammation: from biomarker to therapeutic agent[J]. Biomark Med, 2011, 5(6):731-744.
doi: 10.2217/bmm.11.92 URL |
| [2] |
Tiwari A, Mukherjee B, Dixit M. MicroRNA key to angiogenesis regulation: miRNA biology and therapy[J]. Curr Cancer Drug Targets, 2018, 18(3):266-277.
doi: 10.2174/1568009617666170630142725 pmid: 28669338 |
| [3] |
Kanitz A, Imig J, Dziunycz PJ, et al. The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinoma[J]. PLoS One, 2012, 7(11):e49568.
doi: 10.1371/journal.pone.0049568 URL |
| [4] |
Liu D, Tao T, Xu B, et al. MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)[J]. Biochem Biophys Res Commun, 2014, 445(1):151-156.
doi: 10.1016/j.bbrc.2014.01.140 URL |
| [5] |
Liu J, Yang J, Yu L, et al. miR-361-5p inhibits glioma migration and invasion by targeting SND1[J]. Onco Targets Ther, 2018, 11(1):5239-5252.
doi: 10.2147/OTT URL |
| [6] |
Hou XW, Sun X, Yu Y, et al. miR-361-5p suppresses lung cancer cell lines progression by targeting FOXM1[J]. Neoplasma, 2017, 64(4):526-534.
doi: 10.4149/neo_2017_406 pmid: 28485158 |
| [7] |
Liu B, Lu B, Wang X, et al. MiR-361-5p inhibits cell proliferation and induces cell apoptosis in retinoblastoma by negatively regulating CLDN8[J]. Childs Nerv Syst, 2019, 35(8):1303-1311.
doi: 10.1007/s00381-019-04199-9 URL |
| [8] |
Ma F, Zhang L, Ma L, et al. MiR-361-5p inhibits glycolytic metabolism, proliferation and invasion of breast cancer by targeting FGFR1 and MMP-1[J]. J Exp Clin Cancer Res, 2017, 36(1):158.
doi: 10.1186/s13046-017-0630-1 URL |
| [9] |
Gao F, Feng J, Yao H, et al. LncRNA SBF2-AS1 promotes the progression of cervical cancer by regulating miR-361-5p/FOXM1 axis[J]. Artif Cells Nanomed Biotechnol, 2019, 47(1):776-782.
doi: 10.1080/21691401.2019.1577883 URL |
| [10] |
Wang K, Liu F, Zhou LY, et al. The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489[J]. Circ Res, 2014, 114(9):1377-1388.
doi: 10.1161/CIRCRESAHA.114.302476 pmid: 24557880 |
| [11] |
Dorn GW 2nd, Matkovich SJ. Menage a Trois: Intimate relationship among a microRNA, long noncoding RNA, and mRNA[J]. Circ Res, 2014, 114(9):1362-1365.
doi: 10.1161/CIRCRESAHA.114.303786 URL |
| [12] |
Wang J, Uryga AK, Reinhold J, et al. Vascular smooth muscle cell senescence promotes atherosclerosis and features of plaque vulnerability[J]. Circulation, 2015, 132(20):1909-1919.
doi: 10.1161/CIRCULATIONAHA.115.016457 URL |
| [13] |
Moore KJ, Tabas I. Macrophages in the pathogenesis of atherosclerosis[J]. Cell, 2011, 145(3):341-355.
doi: 10.1016/j.cell.2011.04.005 URL |
| [14] |
Zhang X, Ye Q, Gong D, et al. Apelin-13 inhibits lipoprotein lipase expression via the APJ/PKCα/miR-361-5p signaling pathway in THP-1 macrophage-derived foam cells[J]. Acta Biochim Biophys Sin (Shanghai), 2017, 49(6):530-540.
doi: 10.1093/abbs/gmx038 URL |
| [15] | Ricart JD, Cejudo MP, Peinado OJ, et al. Changes in lipoprotein lipase modulate tissue energy supply during stress[J]. J Appl Physiol(1985), 2005, 99(4):1343-1351. |
| [16] |
Zhang Z, Liu X, Xu H, et al. Obesity-induced upregulation of miR-361-5p promotes hepatosteatosis through targeting Sirt1[J]. Metabolism, 2018, 88:31-39.
doi: 10.1016/j.metabol.2018.08.007 URL |
| [17] | Huang K, Yu X, Yu Y, et al. Long noncoding RNA MALAT1 promotes high glucose-induced inflammation and apoptosis of vascular endothelial cells by regulating miR-361-3p/SOCS3 axis[J]. Int J Clin Exp Pathol, 2020, 13(5):1243-1252. |
| [18] |
Giardina S, Hernández AP, Díaz L, et al. Changes in circulating miRNAs in healthy overweight and obese subjects: Effect of diet composition and weight loss[J]. Clin Nutr, 2019, 38(1):438-443.
doi: S0261-5614(17)31412-7 pmid: 29233588 |
| [19] |
Wang P, Xu TY, Guan YF, et al. Vascular smooth muscle cell apoptosis is an early trigger for hypothyroid atherosclerosis[J]. Cardiovasc Res, 2014, 102(3):448-459.
doi: 10.1093/cvr/cvu056 pmid: 24604622 |
| [20] |
Willis AI, Pierre PD, Sumpio BE, et al. Vascular smooth muscle cell migration: Current research and clinical implications[J]. Vasc Endovascular Surg, 2014, 38(1):11-23.
doi: 10.1177/153857440403800102 URL |
| [21] | Wang M, Li C, Zhang Y, et al. LncRNA MEG3-derived miR-361-5p regulate vascular smooth muscle cells proliferation and apoptosis by targeting ABCA1[J]. Am J Transl Res, 2019, 11(6):3600-3609. |
| [22] |
Castiglioni S, Monti M, Arnaboldi L, et al. ABCA1 and HDL are required to modulate smooth muscle cells phenotypic switch after cholesterol loading[J]. Atherosclerosis, 2017, 266(1):8-15.
doi: 10.1016/j.atherosclerosis.2017.09.012 URL |
| [23] |
Bochem AE, Valk FM, Tolani S, Increased systemic and plaque inflammation in ABCA1 mutation carriers with attenuation by statins[J]. Arterioscler Thromb Vasc Biol, 2015, 35(7):1663-1669.
doi: 10.1161/ATVBAHA.114.304959 URL |
| [24] |
Li C, Guo R, Lou J, et al. The transcription levels of ABCA1, ABCG1 and SR-BI are negatively associated with plasma CRP in Chinese populations with various risk factors for atherosclerosis[J]. Inflammation, 2012, 35(5):1641-1648.
doi: 10.1007/s10753-012-9479-9 URL |
| [25] |
Mulas MF, Maxia A, Dessì S, et al. Cholesterol esterification as a mediator of proliferation of vascular smooth muscle cells and peripheral blood mononuclear cells during atherogenesis[J]. J Vasc Res, 2014, 51(1):14-26.
doi: 10.1159/000355218 URL |
| [26] |
He C, Chen Y, Liu C, et al. Mitofusin 2 decreases intracellular cholesterol of oxidized LDL-induced foam cells from rat vascular smooth muscle cells[J]. J Huazhong Univ Sci Technolog Med Sci, 2013, 33(2):212-218.
doi: 10.1007/s11596-013-1099-6 URL |
| [27] |
Zhang X, Shao R, Gao W, et al. Inhibition of miR-361-5p suppressed pulmonary artery smooth muscle cell survival and migration by targeting ABCA1 and inhibiting the JAK2/STAT3 pathway[J]. Exp Cell Res, 2018, 363(2):255-261.
doi: 10.1016/j.yexcr.2018.01.015 URL |
| [28] |
White HD, Chew DP. Acute myocardial infarction[J]. Lancet, 2018, 372(9638):570-584.
doi: 10.1016/S0140-6736(08)61237-4 URL |
| [29] |
Wang F, Long G, Zhao C, et al. Atherosclerosis-related circulating miRNAs as novel and sensitive predictors for acute myocardial infarction[J]. PLoS One, 2014, 9(9):e105734.
doi: 10.1371/journal.pone.0105734 URL |
| [30] | 王明辉. LncRNA MEG3及miRNA-361-5p在冠状动脉粥样硬化中的作用及机制[D]. 天津:天津医科大学, 2019:38-58. |
| [31] |
Su J, Fang M, Tian B, et al. Atorvastatin protects cardiac progenitor cells from hypoxia-induced cell growth inhibition via MEG3/miR-22/HMGB1 pathway[J]. Acta Biochim Biophys Sin (Shanghai), 2018, 50(12):1257-1265.
doi: 10.1093/abbs/gmy133 URL |
| [32] |
Li X, Zhao J, Geng J, et al. Long non-coding RNA MEG3 knockdown attenuates endoplasmic reticulum stress-mediated apoptosis by targeting p53 following myocardial infarction[J]. J Cell Mol Med, 2019, 23(12):8369-8380.
doi: 10.1111/jcmm.v23.12 URL |
| [33] |
Marzetti E, Calvani R, Cesari M, et al. Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials[J]. Int J Biochem Cell Biol, 2013, 45(10):2288-2301.
doi: 10.1016/j.biocel.2013.06.024 URL |
| [34] | Su B, Wang X, Zheng L, et al. Abnormal mitochondrial dynamics and neurodegenerative diseases[J]. Biochim Biophys Acta, 2010, 1802(1):135-142. |
| [35] |
Wang W, Li L, Lin WL, et al. The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons[J]. Hum Mol Genet, 2013, 22(23):4706-4719.
doi: 10.1093/hmg/ddt319 URL |
| [36] |
Wang K, Liu CY, Zhang XJ, et al. miR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury[J]. Cell Death Differ, 2015, 22(6):1058-1068.
doi: 10.1038/cdd.2014.200 pmid: 25501599 |
| [37] |
Wang K, Sun T, Li N, et al. MDRL lncRNA regulates the processing of miR-484 primary transcript by targeting miR-361[J]. PLoS Genet, 2014, 10(7):e1004467.
doi: 10.1371/journal.pgen.1004467 URL |
| [38] |
Wang HW, Lo HH, Chiu YL, et al. Dysregulated miR-361-5p/VEGF axis in the plasma and endothelial progenitor cells of patients with coronary artery disease[J]. PLoS One, 2014, 9(5):e98070.
doi: 10.1371/journal.pone.0098070 URL |
| [39] | Xie Y, Yao FL, Li X. MicroRNA-361 regulates apoptosis of cardiomyocytes after ischemic-reperfusion injury[J]. Eur Rev Med Pharmacol Sci, 2019, 23(12):5413-5421. |
| [40] | Zhong Z, Zhong W, Zhang Q, et al. Circulating microRNA expression profiling and bioinformatics analysis of patients with coronary artery disease by RNA sequencing[J]. J Clin Lab Anal, 2020, 34(1):e23020. |
| [41] |
Su M, Niu Y, Dang Q, et al. Circulating microRNA profiles based on direct S-Poly(T)Plus assay for detection of coronary heart disease[J]. J Cell Mol Med, 2020, 24(11):5984-5997.
doi: 10.1111/jcmm.v24.11 URL |
| [42] |
Peshkova IO, Schaefer G, Koltsova EK. Atherosclerosis and aortic aneurysm-is inflammation a common denominator?[J]. FEBS J, 2016, 283(9):1636-1652.
doi: 10.1111/febs.13634 pmid: 26700480 |
| [43] |
Yu X, Liu X, Wang R, et al. Long non-coding RNA NEAT1 promotes the progression of hemangioma via the miR-361-5p/VEGFA pathway[J]. Biochem Biophys Res Commun, 2019, 512(4):825-831.
doi: 10.1016/j.bbrc.2019.03.084 URL |
| [44] |
Airhart N, Brownstein BH, Cobb JP, et al. Smooth muscle cells from abdominal aortic aneurysms are unique and can independently and synergistically degrade insoluble elastin[J]. J Vasc Surg, 2014, 60(4): 1033-1041; discussion 1041-1042.
doi: 10.1016/j.jvs.2013.07.097 pmid: 24080131 |
| [45] | Yin RR, Hao D, Chen P. Expression and correlation of MMP-9, VEGF, and p16 in infantile hemangioma[J]. Eur Rev Med Pharmacol Sci, 2018, 22(15):4806-4811. |
| [46] |
Donaldson JW, McKeever TM, Hall IP, et al. The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: A population-based study[J]. Thorax, 2014, 69(2):161-167.
doi: 10.1136/thoraxjnl-2013-203720 pmid: 24188926 |
| [47] |
Delafontaine P, Song YH, Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels[J]. Arterioscler Thromb Vasc Biol, 2004, 24(3):435-44.
pmid: 14604834 |
| [48] |
Bach Leon A. Endothelial cells and the IGF system[J]. J Mol Endocrinol, 2015, 54(1):R1-13.
doi: 10.1530/JME-14-0215 URL |
| [49] | Friedrich CC, Lin Y, Krannich A, et al. Enhancing engineered vascular networks in vitro and in vivo: The effects of IGF1 on vascular development and durability[J]. Cell Prolif, 2018, 51(1): undefined. |
| [50] |
Zawistowski JS, Stalheim L, Uhlik MT, et al. CCM1 and CCM2 protein interactions in cell signaling: Implications for cerebral cavernous malformations pathogenesis[J]. Hum Mol Genet, 2005, 14(17):2521-2531.
pmid: 16037064 |
| [51] |
Kar S, Bali Kiran K, Baisantry A, et al. Genome-wide sequencing reveals micrornas downregulated in cerebral cavernous malformations[J]. J Mol Neurosci, 2017, 61(2):178-188.
doi: 10.1007/s12031-017-0880-6 URL |
| [52] | Galiè N, Humbert M, Vachiery JL, et al. 2015 ESC/ERS Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension[J]. Rev Esp Cardiol (Engl Ed), 2016, 69(2):177. |
| [53] |
Zhang Y, Chen Y, Chen G, et al. Upregulation of miR-361-3p suppresses serotonin-induced proliferation in human pulmonary artery smooth muscle cells by targeting SERT[J]. Cell Mol Biol Lett, 2020, 25:45.
doi: 10.1186/s11658-020-00237-6 pmid: 33061998 |
| [54] |
Dal Monte M, Landi D, Martini D, et al. Antiangiogenic role of miR-361 in human umbilical vein endothelial cells: functional interaction with the peptide somatostatin[J]. Naunyn Schmiedebergs Arch Pharmacol, 2013, 386(1):15-27.
doi: 10.1007/s00210-012-0808-1 URL |
| [55] |
Wei C, Henderson H, Spradley C, et al. Circulating miRNAs as potential marker for pulmonary hypertension[J]. PLoS One, 2013, 8(5):e64396.
doi: 10.1371/journal.pone.0064396 URL |
| [56] |
Shiraev TP, Omari A, Rushworth RL. Trends in pulmonary embolism morbidity and mortality in Australia[J]. Thromb Res, 2013, 132(1):19-25.
doi: 10.1016/j.thromres.2013.04.032 URL |
| [57] |
Wang W, Zhu X, Du X, et al. MiR-150 promotes angiogensis and proliferation of endothelial progenitor cells in deep venous thrombosis by targeting SRCIN1[J]. Microvasc Res, 2019, 123(1):35-41.
doi: 10.1016/j.mvr.2018.10.003 URL |
| [58] |
Ozkok A, Yildiz A. Endothelial Progenitor Cells and Kidney Diseases[J]. Kidney Blood Press Res, 2018, 43(3):701-718.
doi: 10.1159/000489745 URL |
| [59] | Yang X, Song Y, Sun Y, et al. Down-regulation of miR-361-5p promotes the viability, migration and tube formation of endothelial progenitor cells via targeting FGF1[J]. Biosci Rep, 2020, 40(10):BSR20200557. |
| [60] |
Wang X, Sundquist K, Svensson PJ, et al. Association of recurrent venous thromboembolism and circulating microRNAs[J]. Clin Epigenetics, 2019, 11(1):28.
doi: 10.1186/s13148-019-0627-z URL |
| [61] | 牟建军, 任珂宇. 盐敏感性高血压的诊断和机制[J]. 诊断学理论与实践, 2012, 11(6):543-546. |
| [62] |
Kelly TN, He J. Genomic epidemiology of blood pressure salt sensitivity[J]. J Hypertens, 30(5):861-873.
doi: 10.1097/HJH.0b013e3283524949 URL |
| [63] |
Qi H, Liu Z, Liu B, et al. micro-RNA screening and prediction model construction for diagnosis of salt-sensitive essential hypertension[J]. Medicine (Baltimore), 2017, 96(17):e6417.
doi: 10.1097/MD.0000000000006417 URL |
| [64] |
Kanehisa M, Goto S, Sato Y, et al. KEGG for integration and interpretation of large-scale molecular data sets[J]. Nucleic Acids Res, 2012, 40(1):D109-114.
doi: 10.1093/nar/gkr988 URL |
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