Clinical analysis of serum homocysteine in patients with acute ischemic stroke

doi:10.3969/j.issn.1004-583X.2021.11.006

Abstract

Abstract:

Objective To retrospectively analyze the clinical characteristics of serum homocysteine(HCY) in patients with acute ischemic stroke(AIS) for the risk factors associated with increased HCY in AIS secondary prevention. Methods A restrespective study was performed in 1 055 patients diagnozed AIS by diffusion weighted imaging(DWI) and apparent diffusion coefficient(ADC) sequence of cranial MRI in our hospital from January 2019 to December 2019. General informations and HCY levels were based on gender and age. The T test or one-way analysis of variance(ANOVA) method was used to compare the difference between groups and binary Logistic regression method was used to analyze the risk factors for HCY. Results The age range for 1 055 AIS patients was 28 to 98 years, (66.4±11.7) years, HCY 3.7-115.5 μmol/L, (20.1±13.0) μmol/L. The stratified analysis based on gender showed that the age of female was significantly increased when comparing with males, while HCY of female was significantly decreased (all P<0.05). The stratified analysis based on the combination of gender and age showed the difference was not statistically significant in HCY level in males in different age groups (P>0.05). HCY level in females were different and HCY of patients aged over 80 years was significantly increased than aged under 50 years and aged 71-80 years (all P<0.05). Binary logistic regression analysis showed that the independent risk factors for HCY were male, age, and type 2 diabetes mellitus. Conclusion Higher HCY are noted in male, elderly, T2DM of AIS patients, the reduction of HCY may allow the patients to obtain greater benefits in the secondary prevention.

Key words: stroke, brain ischemia, homocysteine, risk factors

CLC Number:

R743

Zhou Haitao, Huang Chao, Wang Hao, Liu Ruihua, Du Yanjiao, Ren Xiangyang. Clinical analysis of serum homocysteine in patients with acute ischemic stroke[J]. Clinical Focus, 2021, 36(11): 991-995.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2021.11.006

https://huicui.hebmu.edu.cn/EN/Y2021/V36/I11/991

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References 37

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项目	数据
性别[例(%)]
男	670(63.5)
女	385(36.5)
年龄(岁)	66.4±11.7
吸烟史[例(%)]
无	669(63.4)
偶尔或戒烟	86(8.2)
经常	300(28.4)
饮酒史[例(%)]
无	915(86.7)
偶尔或戒酒	74(7.0)
经常	66(6.3)
高血压病[例(%)]	612(58.0)
2型糖尿病[例(%)]	436(41.3)
冠心病[例(%)]	218(20.7)
心房颤动[例(%)]	56(5.3)
HCY(μmol/L)	20.1±13.0
≤15.4 μmol/L[例(%)]	460(43.6)
>15.4 μmol/L[例(%)]	595(56.4)

项目	数据
性别[例(%)]
男	670(63.5)
女	385(36.5)
年龄(岁)	66.4±11.7
吸烟史[例(%)]
无	669(63.4)
偶尔或戒烟	86(8.2)
经常	300(28.4)
饮酒史[例(%)]
无	915(86.7)
偶尔或戒酒	74(7.0)
经常	66(6.3)
高血压病[例(%)]	612(58.0)
2型糖尿病[例(%)]	436(41.3)
冠心病[例(%)]	218(20.7)
心房颤动[例(%)]	56(5.3)
HCY(μmol/L)	20.1±13.0
≤15.4 μmol/L[例(%)]	460(43.6)
>15.4 μmol/L[例(%)]	595(56.4)

项目	HCY(μmol/L)			统计值	P值
项目	≤15.4 (n=460)	15.5~30.0 (n=470)	>30.0 (n=125)	统计值	P值
性别[例(%)]
男女	230(50.0) 230(50.0)	335(71.3) 135(28.7)	105(84.0) 20(16.0)	χ²=64.904	<0.05
年龄(岁)	65.3±11.1	68.1±11.6	63.8±13.0	F=10.199	<0.05
高血压病[例(%)]	266(57.8)	272(57.8)	74(59.2)	χ²=0.083	0.959
2型糖尿病[例(%)]	230(50.0)	169(36.0)	37(29.6)	χ²=26.948	<0.05
冠心病[例(%)]	101(22.0)	97(20.6)	20(16.0)	χ²=2.128	0.345
心房颤动[例(%)]	25(5.4)	26(5.5)	5(4.0)	χ²=0.487	0.784

项目	HCY(μmol/L)			统计值	P值
项目	≤15.4 (n=460)	15.5~30.0 (n=470)	>30.0 (n=125)	统计值	P值
性别[例(%)]
男女	230(50.0) 230(50.0)	335(71.3) 135(28.7)	105(84.0) 20(16.0)	χ²=64.904	<0.05
年龄(岁)	65.3±11.1	68.1±11.6	63.8±13.0	F=10.199	<0.05
高血压病[例(%)]	266(57.8)	272(57.8)	74(59.2)	χ²=0.083	0.959
2型糖尿病[例(%)]	230(50.0)	169(36.0)	37(29.6)	χ²=26.948	<0.05
冠心病[例(%)]	101(22.0)	97(20.6)	20(16.0)	χ²=2.128	0.345
心房颤动[例(%)]	25(5.4)	26(5.5)	5(4.0)	χ²=0.487	0.784

性别	例数	年龄 (岁)	HCY (μmol/L)	高血压病 [例(%)]	2型糖尿病 [例(%)]	冠心病 [例(%)]	心房颤动 [例(%)]
男	670	64.9±11.9	22.4±14.8	380(56.7)	277(41.3)	125(18.7)	35(5.2)
女	385	69.1±10.8	16.2±7.7	232(60.3)	159(41.3)	93(24.2)	21(5.5)
统计值		t=-5.949	t=8.898	χ²=1.260	χ²=0	χ²=4.510	χ²=0.026
P值		<0.05	<0.05	0.262	0.989	<0.05	0.872