Abstract:

Objective To investigate the characteristics of lipid accumulation product (LAP) and visceral fat index (VAI) in first-degree relatives of patients with type 2 diabetes mellitus (T2DM) who were impaired glucose regulation (IGR).Methods Totally 212 patients were as subjects among 298 first-degree relatives of T2DM. The clinical data were assessed in the three groups which comprised 115 (normal glucose tolerance, NGT), 93 (impaired glucose regulation, IGR), and 90 (T2DM) patients. Results There was no significant gender difference among the three groups (P>0.05), but differences in age, height, weight, body mass index, and waist circumference among the three groups were all statistically significant (P<0.05). The NGT group was the youngest, and the T2DM group had the largest weight and waist circumference (all P<0.05). The incidence of central obesity in NGT group, IGR group, and T2DM group were 52.17%, 67.74%, and 78.88%, respectively, and the obesity rate in T2DM group was the highest, and the central obesity rate in T2DM group and IGR group was significantly higher than that in NGT group (all P<0.05). There were statistically significant differences in LAP and VAI among the three groups (P<0.05). The T2DM group had the highest LAP and the NGT group had the highest VAI (all P<0.05). LAP and VAI were independent influencing factors for glycated hemoglobin in first-degree relatives of T2DM patients, and LAP was an independent influencing factor for 2-hour blood glucose.Conclusion The central obesity rate in first-degree relatives of T2DM and prediabetes is significantly increased, and the new indexes of LAP and VAI are important influencing factors for glucose metabolic disorders of these patients.

Key words: diabetes mellitus, type 2, obesity, first-degree relatives, lipid accumulation product, visceral adiposity index