Correlation between nonspecific ST-T abnormalities in electrocardiogram and recurrence of acute ischemic stroke

doi:10.3969/j.issn.1004-583X.2023.10.003

Abstract

Abstract: Objective Non-specific ST-T abnormalities (NSSTTAs) in electrocardiogram are common in asymptomatic people, which are risk factors for ischemic stroke. This study aims to investigate the correlation between NSSTTAs in electrocardiogram and recurrence of acute ischemic stroke. Methods Patients with acute ischemic stroke admitted to Department of Emergency, Beijing Tsinghua Changgung Hospital from December 2016 to August 2017 and hospitalized from August 2019 to April 2020 were included in this study, and the telephone / outpatient follow-up was performed. Recurrence of ischemic stroke within one year was the endpoint. According to the recurrence, patients were divided into recurrent group and non-recurrent group. Univariate and multivariate analyses were performed on the two groups to determine the correlation between NSSTTAs and recurrence of acute ischemic stroke. Results A total of 197 patients were included in this study, with the mean age of (66.4±11.4) years. Among them, 27.4% (54/197) were female. They were divided into recurrent group and non-recurrent group according to the 1-year recurrence, involving 11.2%(22/197) relapsed patients and 39.5% (78/197) with NSSTTAs. The proportion of patients with a history of smoking in the recurrent group was significantly higher than that of the non-recurrent group (72.7% vs 50.3%, P=0.047) and that with NSSTTAs in the recurrent group was significantly higher than the non-recurrent group (63.6% vs 36.6%, P=0.014). NSSTTAs (OR=2.847, 95%CI: 1.110-7.305, P=0.030) were the independent risk factor for recurrent ischemic stroke patients after adjustmnet for smoking, hyperhomocysteinemia and hyperlipemia. Conclusion NSSTTAs are common in patients with acute ischemic stroke. Patients with acute ischemic stroke and NSSTTAs may have a higher risk of recurrence.

Key words: ischemic stroke, electrocardiographic, non-specific ST-T abnormalities, recurrence

CLC Number:

R743.3

Xu Wendeng, Shen Yi, Zhang Xiaofeng. Correlation between nonspecific ST-T abnormalities in electrocardiogram and recurrence of acute ischemic stroke[J]. Clinical Focus, 2023, 38(10): 883-886.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2023.10.003

https://huicui.hebmu.edu.cn/EN/Y2023/V38/I10/883

Figures/Tables 3

Tab. 1 Comparison of baseline data between groups

项目	总数 (n=197)	复发组 (n=22)	非复发组 (n=175)	统计值	P值
年龄(岁,$bar{x}$±s)	66.4±11.4	66.0±11.7	69.2±8.4	t=-1.23	0.220
女性[例(%)]	54(27.4)	4(18.2)	50(28.6)		0.447^*
高血压[例(%)]	146(74.1)	18(81.8)	128(73.1)	χ²=0.76	0.381
糖尿病[例(%)]	65(33.0)	10(45.5)	55(31.4)	χ²=1.74	0.187
高脂血症[例(%)]	107(54.3)	14(63.6)	93(53.1)	χ²=0.86	0.352
肾功能不全[例(%)]	21(10.7)	2(9.1)	19(10.9)		1.000^*
脑血管病家族史[例(%)]	38(19.3)	4(18.2)	34(19.4)		1.000^*
高同型半胱氨酸血症[例(%)]	94(47.7)	14(63.6)	80(45.7)	χ²=2.51	0.113
房颤[例(%)]	15(7.6)	3(13.6)	12(6.9)		0.258^*
吸烟史[例(%)]	104(52.8)	16(72.7)	88(50.3)	χ²=3.94	0.047
饮酒史[例(%)]	58(29.4)	6(27.3)	52(29.7)	χ²=0.56	0.813
NSSTTAs[例(%)]	78(39.5)	14(63.6)	64(36.6)	χ²=5.98	0.014

Tab. 2 Multivariate logistic regression analysis of recurrence in patients with ischemic stroke

项目	回归系数	标准误	Wald χ²值	OR值	95%CI	P值
糖尿病	0.714	0.477	2.239	2.042	0.802~5.202	0.135
高同型半胱氨酸血症	0.636	0.484	1.728	1.889	0.732~4.876	0.189
吸烟	0.904	0.515	3.079	2.470	0.900~6.782	2.470
NSSTTAs	1.046	0.481	4.737	2.847	1.110~7.305	0.030

Tab. 3 Analysis of correlation factors of NSSTTAs

项目	NSSTTAs组 ( $n$ =78)	非NSSTTAs组 ( $n$ =119)	统计值	P值
年龄(岁,$bar{x}$±s)	66.1±11.4	66.7±11.7	$t$ =0.350	0.723
女性[例(%)]	20(25.6)	34(28.6)	χ²=20.200	0.652
高血压[例(%)]	59(75.6)	87(73.1)	χ²=0.760	0.381
糖尿病[例(%)]	25(33.6)	40(32.1)	χ²=0.050	0.820
高脂血症[例(%)]	43(55.1)	64(53.8)	χ²=0.030	0.853
肾功能不全[例(%)]	10(12.8)	11(9.2)	χ²=0.630	0.426
脑血管病家族史[例(%)]	13(16.7)	25(21.0)	χ²=0.570	0.450
高同型半胱氨酸血症[例(%)]	41(52.6)	53(44.5)	χ²=1.210	0.270
房颤[例(%)]	6(7.7)	9(7.6)	χ²=0.000	0.973
吸烟史[例(%)]	45(57.7)	59(49.6)	χ²=1.240	0.265
饮酒史[例(%)]	26(33.3)	32(26.9)	χ²=0.940	0.332

Tab. 3 Analysis of correlation factors of NSSTTAs

项目	NSSTTAs组 ( $n$ =78)	非NSSTTAs组 ( $n$ =119)	统计值	P值
年龄(岁,$bar{x}$±s)	66.1±11.4	66.7±11.7	$t$ =0.350	0.723
女性[例(%)]	20(25.6)	34(28.6)	χ²=20.200	0.652
高血压[例(%)]	59(75.6)	87(73.1)	χ²=0.760	0.381
糖尿病[例(%)]	25(33.6)	40(32.1)	χ²=0.050	0.820
高脂血症[例(%)]	43(55.1)	64(53.8)	χ²=0.030	0.853
肾功能不全[例(%)]	10(12.8)	11(9.2)	χ²=0.630	0.426
脑血管病家族史[例(%)]	13(16.7)	25(21.0)	χ²=0.570	0.450
高同型半胱氨酸血症[例(%)]	41(52.6)	53(44.5)	χ²=1.210	0.270
房颤[例(%)]	6(7.7)	9(7.6)	χ²=0.000	0.973
吸烟史[例(%)]	45(57.7)	59(49.6)	χ²=1.240	0.265
饮酒史[例(%)]	26(33.3)	32(26.9)	χ²=0.940	0.332

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