Abstract:

Although 30% of individuals diagnozed with colorectal cancer(CRC) are reported a family history of the disease， only 5% to 6% carry germline mutations in genes associated with known hereditary cancer syndromes. The evaluation and management of families affected with CRC can be complicated by variability in disease phenotypes and the sensitivity of genetic tests is limited. In this review， we examine what is currently known about familial CRC and what we have yet to learn， and explore how novel genomic approaches might be used to identify additional genetic and epigenetic factors implicated in heritable risk for cancer.

Key words: colorectal , neoplasms, genes；mutation