Abstract: Diabetic cardiomyopathy， as one of the major diabetic cardiac complications， is known to be closely related with oxidative stress. Therefore， antioxidant therapy may  be a hot approach to prevent diabetic cardiomyopathy. Metallothionein (MT)， an endogenous， effective and nonspecific antioxidant， Nrf2， a key regulating factor for antioxidant genes， play  important role in antioxidant process. It would be a promising strategy in protecting diabetic cardiac complications if we  explore safe and effective MT and/or Nrf2 inducers to prevent diabetic cardiomyopathy with clearance of various active free radicals.

Key words: diabetic cardiomyopathies, Oxidative stress, antioxidants；Metallothionein, NFE2related factor 2