Abstract: Objective  To study the role of microbiological agents combined with mesalazine in the treatment of ulcerative colitis (UC). Methods  A total of  126  UC patients were enrolled amd randomly divided into two groups, and the control group was given 4 g/d of mesalazin sustainedrelease granules. On the basis of the control group. the combined group also took 500 mg of live combined bacillus subtilis and enterococcus faecium entericcoated capsules 3 times per day for one month. The levels of hemoglobin (HB), albumin (ALB),hypersensitive C reactive protein (hsCRP), erythrocyte sedimentation rate (ESR). interleukin (IL) 6, IL10 and serum calcium binding protein were monitored before and after the treatment. Results  The total effective rate in combined group was significantly higher than that of control group (P<0.01). Compared with control group, ALB and IL10 witnessesd increases in combined group (P<0.05), while   hsCRP, ESR, IL6 and serum S100A12 decreased. Conclusion  Microbiological agents can improve the efficiency, safety and reliability of mesalazin in the treatment of UC.

Key words: colitis, ulcerative, biological agents, mesalamine, treatment