Abstract: Objective  To explore  the correlation between the inflammatory cytokine polymorphisms and cancerrelated fatigue(CRF),  and provide  research basis for the investigation of genetic variation in the development and progression of CRF. Methods  Totally 242 lung cancer patients were divided into CRF group (162) and nonCRF group (80). Genotyping  was carried out according to the polymerase chain reaction restriction fragment length polymorphism(PCR RFLP), then  the distribution of allele frequency and genotypes were analyzed, as well as the correlation between inflammatory cytokine polymorphisms and CRF.Results  There was statistically significant  difference between the distribution of   TNFα308 G/A  and   IL1β511 C/T genotypes(all P<0.05).  After adjusting the confounding factors such as age and gender, multivariate logistic regression showed that patients with GA/AA genotype had a lower risk for CRF by 74%  as compared with  patients with  TNF α308GG genotype(15%92%);  patients with GC/CC genotype had a  lower risk by 78% in comparison with  patients with IL6174GG genotype(0%95%); in the genetic locus of IL1β511C/T,  the patients with CC genotype were 3.96 times more likely to develop CRF than those with TT genotype (95%CI 1.0215.45). Conclusion  Patients with TNFα308GG,  IL6174GG and  IL1β511CC genotypes have a significantly increased risk of CRF.

Key words: pathological condition, , signs and symptoms, cytokines, gene order