Abstract: Objective  To explore the effects of different blood purification methods on microinflammatory status and procalcitonin (PCT) levels in maintenance hemodialysis (MHD) patients. Methods  A total of 120 MHD patients were randomly divided into hemodialysis(HD) group，hemodialysis combined with hemoperfusion (HD+HP) group，hemodialysis combined with hemodiafiltration (HD+HDF) group, hemodialysis combined with hemodiafiltration and hemoperfusion(HD+HDF+HP) group. All groups were observed for 12 months, the changes of interleukin 6(IL6), blood sedimentation (ESR), Creactive protein (CRP) and PCT level were compared before and after 12 months of treatment within each group and among groups in order to evaluate the effects of different blood purification methods on microinflammatory status and PCT in MHD patients. Results   The levels of IL6, ESR, CRP and PCT in HD+HP group, HD+HDF group and HD+HDF+HP group were significantly different from those before treatment (P<0.05). The levels of IL6, CRP and PCT in HD+HP group were better than those in HD+HDF group and HD+HDF+HP group after 12 months of treatment,  and the degree of decline of IL6 was significantly different from that in HD+HDF group and HD+HDF+HP group (P<0.05). Conclusion  Hemodialysis combined with hemoperfusion and (or) hemodiafiltration can improve the microinflammatory status of MHD patients and reduce the level of PCT. However, hemodialysis combined with hemoperfusion have more advantages in improving the microinflammatory state.

Key words: renal dialysis; , inflammatory state, calcitonin