Abstract:

Objective To investigate the relationship between serum amyloid A(SAA), high-sensitivity C-reactive protein(hs-CRP), nitric oxide(NO) and adverse cardiovascular events(ACE) in patients with stable coronary heart disease(CHD).Methods 161 patients with stable CHD were selected retrospectively, and were divided into group A (78 cases with ACE) and group B (83 cases without adverse cardiovascular events) based on one-year follow-up results.The clinical data of the patients were collected, the risk factors of ACE in stable CHD were analyzed, and the predictive value of SAA, hs-CRP and NO for ACE in stable CHD was observed.Results The incidence of diabetes and hypertension in group A was significantly higher than that in group B (P<0.05). SAA and hs-CRP in group A were significantly higher than those in group B, and NO was lower than that in group B (P<0.05). Logistic regression analysis showed that diabetes mellitus, hypertension, SAA, hs-CRP, NO were the risk factors of ACE in stable CHD. ROC curve showing the AUC of SAA, hs-CRP and NO in the diagnosis of ACE in patients with stable CHD was 0.603, 0.633 and 0.706 respectively, the specificity was 0.634, 0.651 and 0.680 respectively, the sensitivity was 0.673, 0.665 and 0.673 respectively, the AUC of the three combined diagnosis of cardiovascular adverse events in patients with stable CHD was 0.744, the specificity was 0.716 and the sensitivity was 0.773. Conclusion High expression of SAA, high expression of hs-CRP and low expression of NO are the risk factors of ACE in patients with stable CHD, and the combination of the three factors has a high clinical value in predicting ACE in patients with stable CHD.

Key words: coronary disease, serum amyloid A, C-reactive protein, nitric oxide, cardiovascular adverse events