Abstract:

Objective To investigate the characteristics of bacterial distribution, resistance and risk factor of death of bacterial infection in leukemia patients. Methods The clinical data of 168 leukemia inpatients complicated by bacterial infection admitted to the Affiliated Hospital of Xuzhou Medical University from January 2015 to December 2019 were collected. WHONET 5.6 and SPSS 19.0 software were used to count the bacterial species, resistance, etc. Logistic regression was used to analyze the risk factor of death. Results A total of 472 bacterial strains were isolated from serum of those 168 patients, the accounted of gram-negative bacterium and gram-positive bacterium were 73.1% and 26.9% respectively. Escherichia coli (28.1%) was most common among bacterium, followed by Klebsiella pneumoniae (19.1%) and Pseudomonas aeruginosa (18.8%). The highest resistance rates were Pseudomonas aeruginosa against ceftriaxone with the rate of 100%, the resistance rates were Staphylococcus aureus against oxacillin with the rate of 50%, and there was no resistance against vancomycin, teicoplanin and linezolid. Serum albumin level (OR=0.879, 95%CI 0.776-0.996, P=0.044) and stenotrophomonas maltophilia infection (OR=2.726, 95%CI 1.241-3.095, P=0.005) were associated with mortality in leukemic patients. Conclusion Bacterial infection is the most common complication and risk factor of death in leukemic patients. By understanding the pathogenic strain and resistance, strengthen the care of patients, and so as to carry out reasonable empirical treatments.

Key words: leukemia, drug resistance, bacterial, risk factors