Correlation analysis of Non-HDL-C/HDL-C and NHR with the severity of coronary artery disease

doi:10.3969/j.issn.1004-583X.2024.02.003

Abstract

Abstract:

Objective To investigate the correlation of non-high-density lipoprotein cholesterol to high density lipoprotein cholesterol ratio (non-HDL-C/HDL-C), neutrophil to high-density lipoprotein cholesterol ratio (NHR) with the severity of coronary artery disease. Methods A total of 284 patients who underwent coronary angiography for the first time in the Cardiology Department of North China University of Technology Affiliated Hospital from January 2022 to June 2023 due to chest tightness and pain were selected. According to the results of coronary angiography, they were divided into the coronary artery disease group (n=223) and control group (n=61). Clinical data (general data and laboratory data), non-HDL-C/HDL-C and NHR were compared between groups. According to the Gensini score, patients in the coronary artery disease group were divided into low-score subgroup (Gensini score<30) and high-score subgroup (Gensini score≥30). Laboratory data of the two subgroups were compared. Spearman correlation analysis of the two subgroups was performed to explore the correlation of Gensini score with non-HDL-C/HDL-C and NHR count. Multivariate logistic regression analysis was performed to explore the influencing factors of high Gensini scores in patients with coronary artery disease. Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive value of non-HDL-C/HDL-C and NHR on high Gensini scores in patients with coronary artery disease. Results The levels of non-HDL-C/HDL-C and NHR in coronary artery disease group were significantly higher than those of control group (P<0.05). Non-HDL-C/HDL-C and NHR levels in patients with high-score subgroup were significantly higher than those of low-score subgroup (P<0.05). Correlation analysis showed that non-HDL-C/HDL-C and NHR were positively correlated with Gensini scores (P<0.05). Multivariate Logistic regression analysis showed that an elevated NHR increased the risk of high Gensini score in patients with coronary artery disease (OR=1.650, 95%CI: 1.262-2.158, P<0.05). ROC curve analysis showed that the area under the curve of non-HDL-C/HDL-C and NHR to predict the severity of coronary lesions was 0.657 (95%CI: 0.582-0.732, P<0.01) and 0.736 (95%CI: 0.666-0.807, P<0.01), respectively. Conclusion Non-HDL-C/HDL-C and NHR are positively correlated with the severity of coronary artery disease, and NHR is an independent predictor of high Gensini score in patients with coronary artery disease.

Key words: coronary artery disease, non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio, neutrophil to high-density lipoprotein cholesterol ratio, Gensini score

CLC Number:

R541.4

Huang Yuling, Zhang Xinyue, Rong Pingping, Yang Wenqi, Cao Xinying, Xing Cainai, Wang Zhijun, Liu Ning. Correlation analysis of Non-HDL-C/HDL-C and NHR with the severity of coronary artery disease[J]. Clinical Focus, 2024, 39(2): 115-120.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2024.02.003

https://huicui.hebmu.edu.cn/EN/Y2024/V39/I2/115

Figures/Tables 5

References 28

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组别	例数	年龄 (岁)		男性 [例(%)]		BMI (kg/m²)		吸烟史 [例(%)]		饮酒史 [例(%)]		高血压 [例(%)]		糖尿病 [例(%)]		收缩压 (mmHg)			舒张压 (mmHg)
对照组	61	56.18±10.45		31(50.8)		25.45±2.52		15(24.6)		12(19.7)		29(47.5)		5(8.2)		133.82±15.45			80.33±10.04
冠状动脉病变组	223	61.91±9.08		111(49.8)		25.68±3.52		62(27.8)		46(20.6)		125(56.1)		52(23.3)		137.92±18.35			82.49±12.10
统计值		t=-3.293		χ²=0.021		χ²=-0.588		χ²=0.250		χ²=0.027		χ²=1.398		χ²=6.827		t=-1.760			t=-1.279
P值		0.001		0.885		0.557		0.617		0.870		0.237		0.009		0.081			0.202
组别	肌酐 (μmol/L)		血糖 (mmol/L)		NEU计数 (×10⁹/L)		TG (mmol/L)		TC (mmol/L)		LDL-C (mmol/L)		HDL-C (mmol/L)		non-HDL-C (mmol/L)		non-HDL-C/ HDL-C	NHR
对照组	71.15±15.38		5.45(4.69, 5.73)		3.22(2.83, 4.02)		1.81(0.97, 2.34)		4.60±0.89		2.82±0.88		1.42±0.33		3.18±0.86		2.38±0.89	2.37(1.85, 3.20)
冠状动脉病变组	67.77±13.79		5.86(5.15, 6.99)		3.55(2.77, 4.39)		1.33(1.04, 1.79)		4.82±1.10		2.98±0.86		1.31±0.31		3.52±0.98		2.80±0.88	2.70(2.05, 3.82)
统计值	t=1.655		Z=-6.453		Z=-3.255		Z=-0.099		t=-1.47		t=-1.361		t=2.501		t=-2.437		t=-3.293	Z=-6.328
P值	0.099		<0.01		0.001		0.921		0.143		0.175		0.013		0.015		0.001	<0.01

组别	例数	年龄 (岁)		男性 [例(%)]		BMI (kg/m²)		吸烟史 [例(%)]		饮酒史 [例(%)]		高血压 [例(%)]		糖尿病 [例(%)]		收缩压 (mmHg)			舒张压 (mmHg)
对照组	61	56.18±10.45		31(50.8)		25.45±2.52		15(24.6)		12(19.7)		29(47.5)		5(8.2)		133.82±15.45			80.33±10.04
冠状动脉病变组	223	61.91±9.08		111(49.8)		25.68±3.52		62(27.8)		46(20.6)		125(56.1)		52(23.3)		137.92±18.35			82.49±12.10
统计值		t=-3.293		χ²=0.021		χ²=-0.588		χ²=0.250		χ²=0.027		χ²=1.398		χ²=6.827		t=-1.760			t=-1.279
P值		0.001		0.885		0.557		0.617		0.870		0.237		0.009		0.081			0.202
组别	肌酐 (μmol/L)		血糖 (mmol/L)		NEU计数 (×10⁹/L)		TG (mmol/L)		TC (mmol/L)		LDL-C (mmol/L)		HDL-C (mmol/L)		non-HDL-C (mmol/L)		non-HDL-C/ HDL-C	NHR
对照组	71.15±15.38		5.45(4.69, 5.73)		3.22(2.83, 4.02)		1.81(0.97, 2.34)		4.60±0.89		2.82±0.88		1.42±0.33		3.18±0.86		2.38±0.89	2.37(1.85, 3.20)
冠状动脉病变组	67.77±13.79		5.86(5.15, 6.99)		3.55(2.77, 4.39)		1.33(1.04, 1.79)		4.82±1.10		2.98±0.86		1.31±0.31		3.52±0.98		2.80±0.88	2.70(2.05, 3.82)
统计值	t=1.655		Z=-6.453		Z=-3.255		Z=-0.099		t=-1.47		t=-1.361		t=2.501		t=-2.437		t=-3.293	Z=-6.328
P值	0.099		<0.01		0.001		0.921		0.143		0.175		0.013		0.015		0.001	<0.01

组别	例数	NEU计数 (×10⁹/L)	血糖 (mmol/L)	肌酐 (μmol/L)	LDL-C (mmol/L)	HDL-C (mmol/L)	non-HDL-C (mmol/L)	non-HDL-C/ HDL-C	NHR
低分值亚组	159	3.19(2.65, 4.15)	5.67(5.10, 6.66)	66.26±13.77	2.96±0.81	1.36±0.31	3.48±0.94	2.67±0.88	2.39(1.91, 3.35)
高分值亚组	64	4.01(3.40, 5.13)	6.62(5.59, 8.69)	71.50±13.19	3.05±0.96	1.17±0.26	3.59±1.10	3.12±0.81	3.45(2.80, 5.35)
统计值		Z=-4.454	Z=-4.035	t=-2.598	t=-0.681	t=4.33	t=-0.749	t=-3.517	Z=-5.514
P值		<0.01	<0.01	0.010	0.496	<0.01	0.454	0.001	<0.01

组别	例数	NEU计数 (×10⁹/L)	血糖 (mmol/L)	肌酐 (μmol/L)	LDL-C (mmol/L)	HDL-C (mmol/L)	non-HDL-C (mmol/L)	non-HDL-C/ HDL-C	NHR
低分值亚组	159	3.19(2.65, 4.15)	5.67(5.10, 6.66)	66.26±13.77	2.96±0.81	1.36±0.31	3.48±0.94	2.67±0.88	2.39(1.91, 3.35)
高分值亚组	64	4.01(3.40, 5.13)	6.62(5.59, 8.69)	71.50±13.19	3.05±0.96	1.17±0.26	3.59±1.10	3.12±0.81	3.45(2.80, 5.35)
统计值		Z=-4.454	Z=-4.035	t=-2.598	t=-0.681	t=4.33	t=-0.749	t=-3.517	Z=-5.514
P值		<0.01	<0.01	0.010	0.496	<0.01	0.454	0.001	<0.01

自变量	r_s值	P值
NHR	0.404	<0.01
non-HDL-C/HDL-C	0.334	<0.01