Abstract: Objective  To explore the efficacy of butylphthalide injection in the treatment of different subtypes of acute cerebral infarction(ACI), based on TOAST classification. MethodsA total of 299 patients with ACI were randomly divided into two groups . The control group was treated according to the guidelines for the diagnosis and treatment of acute   ischemic stroke,  while the observation group was treated with butylphthalide injection on the basis of the guidelines. All patients were carried out by TOAST typing on admission procedures. NIHSS score and BI score were recorded in two groups of patients on admission and after two weeks and four weeks of treatment. Comparison was performed in the curative effect of two  groups and different subtypes of patients.Results  Compared with the control group, the NIHSS score of observation group decreased while BI score increased after two weeks and four weeks of treatment(P<0.05). The curative effect of observation group was better than that of control group(P<0.05). After the treatment, the NIHSS of the three subtypes all saw decrease, while BI scores increased. However,  LAA subtype changed more obviously.  Significant statistical differences existed among the three subgroups,  and among the interactions between the groups, at different time(P<0.05).Conclusion  Butylphalide injection has a good effect on ACI. The effect of butylphthalide injection on LAA subtype are better than that of CE subtype and SAO subtype.

Key words: brain infarction, butylphthalide and sodium chloride injection, TOAST type, curative effect