Abstract: Objective  To investigate the changes of serum uric acid on shortterm outcome in acute ischemic stroke patients treated with intravenous recombinant tissue plasminogen activator. Methods  A total of 122 acute ischemic stroke patients treated with thrombolysis in our stroke unit from 2015 to 2018 was included.  At 90 days,  the scores of the modified Rankin Scale（mRS）>2 was defined as poor prognosis and the scores of mRS≤2 was defined as excellent outcome. The demographic data, clinical data,  and laboratory parameters on adimission were prospectively collected. Stepwise Logistic regression moedels were used to analyze potential factors affecting the prognosis. The demographic data (age,  sex,  hypertension,  diabetes mellitus,  atrial fibrillation,  drinking,  smoking),  clinical data (NIHSS,  modified Rankin Scale,  the time between onset and thrombolysis) and laboratory indicators (uric acid,  cholesterol,  triglyceride,  low density lipoprotein cholesterol,  high density lipoprotein cholesterol) were compared between the two groups. Results  The demographic data (age,  sex,  hypertension,  diabetes mellitus,  drinking,  smoking) and laboratory indexes (cholesterol,  triglyceride,  low density lipoprotein,  high density lipoprotein) were not significantly different between the two groups. Atrial fibrillation,  the scale of NIHSS before thrombolysis,  time from onset to thrombolysis and the level of serum uric acid were significantly different between the two groups. Logistic regression analysis revealed that high level of serum uric acid was related to excellent outcome. Conclusion  Increased serum uric level was associated with better prognosis in acute ischemic stroke patients treated with intravenous recombinant tissue plasminogen activator.

Key words: brain infarction, thrombolysis, uric acid, prognosis