Clinical Focus ›› 2021, Vol. 36 ›› Issue (9): 843-849.doi: 10.3969/j.issn.1004-583X.2021.09.016
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2021-05-05
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2021-09-20
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2021-10-05
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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2021.09.016
疾病类型 | 相关通路 | ceRNA | 靶基因 | 生物学功能 |
---|---|---|---|---|
AS | APJ/PKCa JAK2/STAT3 | MALAT1 MEG3 | LPL Sirt1 SOCS3 SH2B1 ABCA1 | 参与糖、脂质代谢、细胞增殖转移,抑制炎症因子 |
AMI | 未知 | MEG3 | PHB1 VEGF BCL2/BAX p53 | 参与血管生成、细胞增殖转移、抑制凋亡,影响线粒体功能 |
HA HHT CCM | TGFβ/BMP | NEAT1 | VEGFA IGF1 RAC1 CCM2 | 参与血管生成、细胞增殖转移、细胞外基质降解 |
PAH | JAK/STAT3 | 未知 | SERT VEGF ABCA1 | 参与血管重塑、脂质代谢、细胞增殖转移 |
VTE | TGFβ1/2 | 未知 | FGF1 | 参与血管生成、细胞增殖转移 |
SSH | 未知 | OTX1-7:1 | PRKCA | 参与钙信号、血管平滑肌收缩、钠重吸收,调控钠离子转运体 |
疾病类型 | 相关通路 | ceRNA | 靶基因 | 生物学功能 |
---|---|---|---|---|
AS | APJ/PKCa JAK2/STAT3 | MALAT1 MEG3 | LPL Sirt1 SOCS3 SH2B1 ABCA1 | 参与糖、脂质代谢、细胞增殖转移,抑制炎症因子 |
AMI | 未知 | MEG3 | PHB1 VEGF BCL2/BAX p53 | 参与血管生成、细胞增殖转移、抑制凋亡,影响线粒体功能 |
HA HHT CCM | TGFβ/BMP | NEAT1 | VEGFA IGF1 RAC1 CCM2 | 参与血管生成、细胞增殖转移、细胞外基质降解 |
PAH | JAK/STAT3 | 未知 | SERT VEGF ABCA1 | 参与血管重塑、脂质代谢、细胞增殖转移 |
VTE | TGFβ1/2 | 未知 | FGF1 | 参与血管生成、细胞增殖转移 |
SSH | 未知 | OTX1-7:1 | PRKCA | 参与钙信号、血管平滑肌收缩、钠重吸收,调控钠离子转运体 |
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