Changes of vitamin A in children with community-acquired pneumonia and corresponding immune function

doi:10.3969/j.issn.1004-583X.2022.07.007

Abstract

Abstract:

Objective This study aimed to explore the correlation between serum vitamin A (VA) and immune function in children with community acquired pneumonia (CAP), and to provide information for the risk of pneumonia. Methods Totally 63 cases severe CAP (SCAP group) admitted to the pediatric intensive care unit (PICU) of the First Affiliated Hospital of Xinxiang Medical College, 30 cases in mild CAP (MCAP group), and 30 synchronous healthy children (control group) were enrolled. The serum levels of VA and immunoglobulin (Ig) IgG, IgA, and IgM, and T lymphocyte subsets (total T lymphocytes, CD4, CD8, CD4/CD8) in all patients were detected, The correlation between the VA level and immune-related indicators in SCAP group was assessed. Results Difference was not statistically significant in gender and age among the three groups. The average content of serum VA in the control group, MCAP group, and SCAP group were 0.36, 0.25, and 0.19 mg/L respectively. The content of VA in the two CAP group was significantly lower than the control group, and SCAP group was common ( $P$ <0.05). According to the VA diagnostic criteria recommended by the World Health Organization's (WHO), the rate of clinical/subclinical deficiency of VA in the control group, MCAP group, and SCAP group were 10.00%,36.67%, and 61.90%, respectively; and there was a significant difference among the three groups ( $P$ <0.05). The serum LG level in the two CAP group was significantly lower than that in the control group; and the SCAP group was significantly lower than the MCAP group ( $P$ <0.05);The serum levels of total T lymphocytes, CD4, CD8, and CD4/CD8 in SCAP group were 53.28%,30.26%, 20.24%, and 1.59, respectively.The analysis of the relationship between VA levels and immune-related indicators found that VA levels were positively correlated with Ig (IgG, IgA, IgM) levels, total T lymphocytes, and CD4, but were not correlated with CD8 levels. Conclusion The level of serum VA in children with CAP was associated with the risk of pneumonia and the immune function.

Key words: community acquired pneumonia, vitamin A, immune function

CLC Number:

R563.1

Zhang Dong, Wang Zhiyuan, Li Shujun. Changes of vitamin A in children with community-acquired pneumonia and corresponding immune function[J]. Clinical Focus, 2022, 37(7): 623-626.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2022.07.007

https://huicui.hebmu.edu.cn/EN/Y2022/V37/I7/623

Figures/Tables 4

组别	例数	性别[例(%)]		年龄 (月)	VA (mg/L)
组别	例数	男	女	年龄 (月)	VA (mg/L)
对照组	30	17(56.7)	13(43.0)	10(2,24)	0.36±0.03
MCAP组	30	15(50.0)	15(50.0)	9(2,16)	0.25±0.02
SCAP组	63	38(60.3)	25(39.7)	8(3,12)	0.19±0.01
统计值		χ²=0.883		$K W$ =0.875	$F$ =27.61
$P$ 值		0.643		0.266	<0.05

组别	例数	性别[例(%)]		年龄 (月)	VA (mg/L)
组别	例数	男	女	年龄 (月)	VA (mg/L)
对照组	30	17(56.7)	13(43.0)	10(2,24)	0.36±0.03
MCAP组	30	15(50.0)	15(50.0)	9(2,16)	0.25±0.02
SCAP组	63	38(60.3)	25(39.7)	8(3,12)	0.19±0.01
统计值		χ²=0.883		$K W$ =0.875	$F$ =27.61
$P$ 值		0.643		0.266	<0.05

组别	例数	临床/亚临床缺乏	可疑亚临床缺乏	正常
对照组	30	3(10.00)	10(33.33)	17(56.67)
MCAP组	30	11(36.67)	13(43.33)	6(20.00)
SCAP组	63	39(61.90)	15(23.81)	9(14.29)
χ²值			22.99
$P$ 值			<0.05

组别	例数	临床/亚临床缺乏	可疑亚临床缺乏	正常
对照组	30	3(10.00)	10(33.33)	17(56.67)
MCAP组	30	11(36.67)	13(43.33)	6(20.00)
SCAP组	63	39(61.90)	15(23.81)	9(14.29)
χ²值			22.99
$P$ 值			<0.05

组别	例数	IgG(g/L)	IgA(g/L)	IgM(g/L)
对照组	30	10.20±0.81	1.42±0.17	1.46±0.15
MCAP组	30	7.20±0.52^*	0.88±0.16^*	1.01±0.09^*
SCAP组	63	5.33±0.44^*#	0.30±0.04^*#	0.75±0.06^*#
$F$ 值		18.24	25.89	14.33
$P$ 值		<0.05	<0.05	<0.05

组别	例数	IgG(g/L)	IgA(g/L)	IgM(g/L)
对照组	30	10.20±0.81	1.42±0.17	1.46±0.15
MCAP组	30	7.20±0.52^*	0.88±0.16^*	1.01±0.09^*
SCAP组	63	5.33±0.44^*#	0.30±0.04^*#	0.75±0.06^*#
$F$ 值		18.24	25.89	14.33
$P$ 值		<0.05	<0.05	<0.05

指标	$r$ 值	$P$ 值
IgG	0.454	<0.05
IgA	0.518	<0.05
IgM	0.474	<0.05
总T淋巴细胞(%)	0.449	<0.05
CD4(%)	0.372	<0.05
CD8(%)	-0.02	0.927

指标	$r$ 值	$P$ 值
IgG	0.454	<0.05
IgA	0.518	<0.05
IgM	0.474	<0.05
总T淋巴细胞(%)	0.449	<0.05
CD4(%)	0.372	<0.05
CD8(%)	-0.02	0.927

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