Abstract:

Objective To report a case of TFEB translocation renal cell carcinoma and review the literature, to explore its clinical and imaging features, in order to improve the understanding of the disease. Methods The clinical and imaging data of a case of TFEB translocation renal cell carcinoma were retrospectively analyzed, the “TFEB translocation renal cell carcinoma”, “MiT-family translocation renal cell carcinoma”, “6p21 translocation renal cell carcinoma”, and “t (6;11)(p21; q12)” were selected as keywords. The papers collected by China National Knowledge Internet (CNKI), Wanfang database and PubMed from January 2010 to present were retrieved. Clinical features and imaging characteristics of TFEB translocation renal cell carcinoma were summarized. Results A 54-year-old male patient was admitted to the hospital because of backache and gross hematuria. The computed tomography (CT) scan showed a cystic and solid mass with clear borders, accompanied by hemorrhage and calcification. The enhanced scan showed uneven enhancement and no distant metastasis. The 13 confirmed cases reported in the literature had a male to female ratio of 8∶5; the average age was 37.8 years; the average maximum diameter of the tumor was about 7.7 cm. The surgical resection of the tumor was performed in all cases, one case had bilateral lung metastasis before surgery, and the other 12 cases had no metastasis. The masses had clear boundaries, mainly cystic and solid mixed density, and the enhancement mode was mainly continuous mild to moderate enhancement. Conclusion TFEB translocation renal cell carcinoma is a rare non-invasive low-grade malignant tumor, which occurs in young patients with well-defined, mild to moderately enhanced cystic-solid masses, the possibility of TFEB translocation renal cell carcinoma needs to be considered.

Key words: carcinoma, renal cell, TFEB translocation renal cell carcinoma, MiT family translocation renal cell carcinoma