临床荟萃

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5-氨基水杨酸在炎症性肠病中的合理应用

  

  1. 河北医科大学第二医院 消化内科 河北省消化病重点实验室 河北省消化病研究所,河北 石家庄 050000
  • 出版日期:2016-08-05 发布日期:2016-07-30
  • 通讯作者: 通信作者:张晓岚,Email: xiaolanzh@126.com
  • 作者简介:郭金波,男,医学博士。学术兼职:河北省医学会第六届消化病学分会青年学组秘书。参与发表SCI论文2篇、中文核心期刊文章6篇;多篇会议投稿被APDW、AASLD及DDW等国际消化会议和国内消化会议接受。参研省级科研课题4项。

Reasonable application of  5aminosalicylic acid in inflammatory bowel  disease treatment

  1. Department of Gastroenterology, the Second Hospital of Hebei Medical University;
    Hebei Key Laboratory of Gastroenterology; Hebei Institute of Gastroenterology, Shijiazhuang 050000,China
  • Online:2016-08-05 Published:2016-07-30
  • Contact: Corresponding author: Zhang Xiaolan,Email: xiaolanzh@126.com

摘要: 5-氨基水杨酸(5-ASA)是临床应用最早、不良反应最少、使用最多的治疗炎症性肠病(IBD)的药物,但实际应用中仍存在诸多不规范的情况。本文从5-ASA用于IBD治疗的发展史和治疗机制、5-ASA在IBD中的合理应用、5-ASA对IBD相关结直肠癌的预防作用以及5-ASA的不良反应4个方面介绍其在IBD中的应用,旨在全面了解5-ASA在IBD治疗中的作用,使其更合理、规范地应用于临床。

关键词: 炎性肠疾病, 结直肠肿瘤, 5-氨基水杨酸, 治疗

Abstract: 5-aminosalicylic acid (5-ASA) is the earliest medication widely used for inflammatory bowel disease (IBD) treatment with little side effect. However, improper use of drugs often appear in clinic. The present article mainly introduced the development history, therapeutic mechanism,reasonable application and side effect of 5-ASA in IBD treatment as well as its chemopreventive effect on IBDassociated colonic cancer with the purpose of  5-ASA beneficial use.

Key words: inflammatory bowel disease, colorectal neoplasms ;5-aminosalicylic acid, treatment