胱抑素C与急性ST段抬高型心肌梗死患者重度冠状动脉病变的相关性

doi:10.3969/j.issn.1004-583X.2016.10.009

临床荟萃

胱抑素C与急性ST段抬高型心肌梗死患者重度冠状动脉病变的相关性

天津医科大学第二医院心脏科，天津 300211

出版日期:2016-10-05 发布日期:2016-10-11
通讯作者: 通信作者：徐延敏，Email：xuyanminphdmd@sina.com

Relationship between cystatin C and severe coronary artery disease in patients with acute ST elevation myocardial infarction

Department of Cardiology， the Second Hospital of Tianjin Medical University， Tianjin 300211， China

Online:2016-10-05 Published:2016-10-11
Contact: Corresponding author：Xu Yanmin，Email：xuyanminphdmd@sina.com

摘要/Abstract

摘要： 目的探讨胱抑素C（Cys C）对急性ST段抬高型心肌梗死（STEMI）患者重度冠状动脉病变的预测及其临床应用价值。方法选取我院STEMI患者321例，根据Cys C水平四分位数分为C1组（≤0.65 mg/L）、C2组（0.65～1.04 mg/L）、C3组（＞1.04 mg/L），收集患者一般临床资料、实验室检查指标、冠状动脉造影结果、住院期间不良事件，分析Cys C水平与Gensini评分、Syntax评分及化验指标的相关性。同时根据Gensini评分将患者分为轻中度病变组（≤80分）及重度病变组（＞80分），分析Cys C及STEMI危险因素指标对冠状动脉病变严重程度的风险比及预测价值。结果C3组Gensini评分、Syntax评分较其他两组明显升高（P＜0.01），Cys C与冠心病Gensini评分、Syntax评分呈正相关（r=0.256；0.353，P＜0.01），此外，Cys C对重度STEMI血管病变的预测价值与肌钙蛋白相当。结论Cys C对STEMI患者重度冠状动脉病变具有很好的预测价值。

关键词: 心肌梗死, 胱抑素C, Gensini评分, Syntax评分

Abstract: ObjectiveTo explore the value of cystatin C in prediction of severe coronary artery disease and its clinical application in patients with acute ST elevation myocardial infarction (STEMI). MethodsA total of 321 patients with STEMI were divided into three groups according to levels of cystatin C. The study included clinical data， laboratory examination indicators， the results of coronary angiography and adverse events during hospitalization. The relationship between cystatin C and Gensini score， Syntax score and other indicators were analyzed. At the same time， the patients were divided into mild to moderate stenosis group and severe disease group according to Gensini score. Logistic regression analysis model， ROC curve analysis of cystatin C and STEMI risk factors on the severity of coronary artery disease were analyzed. ResultsThe Gensini score of high level of cystatin C group (Group C3) was significantly increased than that of the other two groups (P<0.01). Cystatin C was positively associated with a higher Gensini and Syntax scores (r=0.256; 0.353，P<0.01). In addition， the value of Cystatin C on predicting the severe STEMI vascular lesions was equal to troponin. ConclusionSerum cystatin C level significantly increased in STEMI patients and it has positively relationship and good predictive value with the severity of coronary artery lesions.

Key words: myocardial infarction, cystatin C, gensini score, syntax score

李姮，韩聪聪，任焘君，郭星梅，徐延敏. 胱抑素C与急性ST段抬高型心肌梗死患者重度冠状动脉病变的相关性[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2016.10.009.

Li Heng， Han Congcong， Ren Taojun， Guo Xingmei， Xu Yanmin. Relationship between cystatin C and severe coronary artery disease in patients with acute ST elevation myocardial infarction[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2016.10.009.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2016.10.009

https://huicui.hebmu.edu.cn/CN/Y2016/V31/I10/1080

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胱抑素C与急性ST段抬高型心肌梗死患者重度冠状动脉病变的相关性

Relationship between cystatin C and severe coronary artery disease in patients with acute ST elevation myocardial infarction

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