关键词: 紫癜, 过敏性；儿童；肾炎；流行病学

Abstract: Objective  To investigate the epidemiological characteristics of HenochSchonlein purpura (HSP) and to study the characteristics of each phenotype and risk factors of HSPN.  Methods  The HSP  patients  from 2010  to  2016  were enrolled in  the Third Affiliated Hospital of Soochow University and the clinical data were analyzed retrospectively.Results  The onset age of HSP was 2 years13 years old， mainly in autumn and winter.The  precursor infection was one of the commonest causes; as the first symptom， skin purpura  accounted  for 94.0%(441/469)， joint discomfort as the first symptom accounted  for 2.6%(12/439)，3.4%(16/469) were abdominal symptoms; HSPN recurrence  accouted for 12.3%(58/469)， of which HSPN group of 2.6%(12/469);  ANCA was negative in all of children  and  the total IgE  positive rate was 50.7%(238/469). The increase  of WBC and  Ddimer were  the risk of gastrointestinal bleeding.  The  multivariate analysis showed that age， Ddimer， CysC，malb increased the risk of renal involvement.Conclusion  HSP children rash easy to relapse， especially  in  HenochSchonlein purpura nephritis patients.The increase  of WBC and Ddimer may indicate increased  the risk of gastrointestinal bleeding.The age， two Ddimer， serum CysC， microalbuminuria was correlated with the incidence of HSPN.Thus，we should be aware of the occurrence of HSPN when examining abnormalities.HenochSchonlein purpura is generally a benign disease， as a  selflimiting disease with  good prognosis.

Key words: purpura, SchoenleinHenoch, child, nephritis, epidemiology