关键词: 糖尿病, 2型, 糖尿病神经病变, 神经传导, 踝肱指数

Abstract: Objective  To investigate the related factors of diabetic peripheral neuropathy in patients with type 2 diabetes mellitus(T2DM). Methods  One hundred and fourteen patients with T2DM were included. Diabetic peripheral neuropathy was evaluated according to the motor and sensory nerve conduction velocity， and the patient  were divided into diabetic peripheral neuropathy group (DPN group， 73 cases) and non diabetic peripheral neuropathy group (NDPN group， 41 cases). The gender， age， duration， body mass index， waist circumference， fasting blood glucose， postprandial blood glucose， glycosylated hemoglobin (HbA1c)， the blood lipid， motor and sensory nerve conduction velocity， carotid intimamedia thickness， foot and ankle brachial index， sensory threshold index were analyzed. Results  The age， disease  course， fasting and postprandial blood glucose and HbA1c in DPN group were significantly higher than those in NDPN group (P<0.05). The motor and sensory nerve conduction velocity was significantly lower than that in group NDPN (P<0.01)， the carotid intimamedia thickness and foot sensation threshold were significantly higher than those in group NDPN (P<0.05).  The data showed that advanced age， long duration and high HbA1c levels in patients with T2DM were independent risk factors of DPN (P<0.05). Conclusion  DPN is associated with age， duration and HbA1c level in patients with T2DM.

Key words: diabetes mellitus, type 2；diabetic neuropathies；neural conduction；ankle brachial index