临床荟萃
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摘要： 艰难梭菌是抗生素相关性腹泻及伪膜性肠炎等医院获得性感染性疾病的主要病原菌。近些年高致病性BI/NAP1/027核糖体分型成为流行菌株，时常出现感染爆发流行，复发率及病死率呈上升趋势，造成极大的人力、财力、物力损失。因此，重视起艰难梭菌感控是必要的。疫苗研究是防治艰难梭菌的重要手段，国外研制艰难梭菌疫苗近20年，取得了一定进展。本文将对艰难梭菌预防及疫苗研究现状进行总结，期望能为临床医师和科研人员提供参考。
关键词: 梭菌感染, 腹泻, 疫苗
Abstract: Clostridium difficile infection (CDI) is recognized as a major cause of nosocomial diseases ranging from antibioticassociated diarrhea to fulminant colitis. The past two decades saw C. difficile hyper virulent BI/NAP1/027 strain being associated with increased incidence and severity of CDI, which involved considerable human resourches, financial and material loss. Thus, the development of novel therapeutics is imperative for the prevention and treatment of CDI. Vaccination can represent a valuable strategy to prevent CDI and the study on experimental vaccines against C. difficile has undergone for almost 20 years. This review summarizes recent achievements and remaining challenges in the field of C. difficile vaccines in a bid to provide references for clinical work and scientific research.
Key words: Clostridium infections; , diarrhea; , vaccine
陈烨，王浦. 艰难梭菌感染的预防及疫苗研究进展[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2018.05.006.
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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2018.05.006
https://huicui.hebmu.edu.cn/CN/Y2018/V33/I5/390
