关键词: 胰腺炎, 肠道屏障功能, 体表胃肠起搏治疗, 胃肠动力障碍

Abstract: Objective  To observe the effect of surface gastrointestinal pacing therapy on intestinal barrier function in patients with severe acute pancreatitis (SAP). Methods  A total of 47 patients with SAP were divided into the control group (22 cases) and the experimental group (25 cases). Apart from the treatment received by the control group, which included conventional treatment such as  fasting,  gastrointestinal decompression,  antiinfection,  antiinflammatory (ulinastatin),  inhibition of gastric acid secretion (Omeprazole),  somatostatin (somatostatin injection), patients in the experimental group also need to receive the treatment of surface gastrointestinal pacing therapy. The number of bowel sounds and plasma endotoxin, Dlactic acid, and serum diamine oxidase (DAO) levels were monitored respectively before the treatment and 24, 48, and 96 h after the treatment. The number of cases whose abdominal pain and abdominal distension had disappeared  24, 48, and 96 h after the treatment was measured.Results  The levels of endotoxin,  Dlactic acid, and DAO in two groups 24, 48, and 96 h after the treatment were significantly lower than those before the  treatment (P<0.05), and the number of bowel sounds increased 48 and 96 h after the treatment(all P<0.05). There were no statistical significance between the two groups in terms of the comparison of frequency of bowel sounds and endotoxin,  Dlactate and DAO 24 and 48 h after the treatment (all P>0.05). Compared with the control group, the number of patients in the experimental group with abdominal pain,  abdominal distension and decreasing borborygmus increased significantly, and their levels of endotoxin, Dlactic acid, and DAO significantly decreasedg 96 h after the treatment(all P<0.05).Conclusion  The use of surface gastrointestinal pacing therapy in SAP patients can restore gastrointestinal motility as soon as possible,  thereby improving gastrointestinal barrier function,  reducing endotoxin translocation,  preventing intestinal failure,  and promoting early recovery of the disease. It is a simple and worthwhile promotion of supplementary treatment measures.

Key words: pancreatitis, intestinal barrier function, surface gastroenteric pacing, gastrointestinal motility disorder