关键词: 肾功能衰竭,  , 慢性, 活血, 血瘀质

Abstract: Objective  To observe the effect of Huoxue Yishen Decoction on blood stasis constitution of chronic renal failure (CRF) and to explore the correlation between blood stasis constitution and CRF clinical efficacy. Methods  A total of  100 CRF patients who met the inclusion criteria were divided into the control group and the treatment group by randomized blind method. The control group was treated with conventional western medicine,  while the treatment group was treated with Huoxue Yishen decoction on the basis of conventional western medicine. The treatment continued for eight weeks. The scores of TCM constitution,  TCM syndrome points,  blood lipid,  blood rheology and renal function of two groups before and after treatment were recorded,  and the relationship between the degree of blood stasis constitution and the clinical efficacy of  two groups was analyzed.Results  The total effective rate of  treatment group was 86.3%,  and that of control group was 75.5%. There were statistically significant differences  in improving the clinical syndromes of traditional chinese medicine,  the degree of blood stasis constitution,  plasma imbalance,  reducing blood creatinine,  cholesterol,  triglyceride,  plasma viscosity,  and the clearance rate of endogenous creatinine between two groups (P<0.05). The degree of blood stasis bias was correlated with the clinical efficacy of patients with CRF. Conclusion  Huoxue Yishen  decoction has good clinical effect on blood stasis constitution  of  CRF. The higher the degree of blood stasis bias,  the worse the clinical efficacy of CRF. Blood stasis constitution may be one of the factors that predispose or aggravate CRF.

Key words: kidney failure, , chronic, activating blood, blood stasis constitution