中度稳定期慢性阻塞性肺疾病疲劳与多维度指标的关系

doi:10.3969/j.issn.1004-583X.2022.08.005

摘要/Abstract

摘要：

目的探讨中度稳定期慢性阻塞性肺疾病(慢阻肺)患者疲劳与营养指标、生活质量指标、炎症指标、精神情绪指标的关系。方法采用前瞻性研究,根据一般疲劳定义,从慢阻肺患者中随机选取中度稳定期慢阻肺疲劳患者30例(疲劳组)与中度稳定期慢阻肺非疲劳患者26例(非疲劳组)。收集两组一般资料、营养指标、生活质量指标、炎症指标、精神情绪指标,并进行比较。结果两组性别、年龄、吸烟指数等方面差异无统计学意义(均P>0.05);与非疲劳组相比,疲劳组白蛋白、血红蛋白、体重指数、第1秒用力呼气容积占预计值的百分比(percent predicted forced expiratory volume in one-second, FEV1%)、6 min步行距离(6-minute walk distance, 6MWD)均显著降低(P<0.05),慢性阻塞性肺疾病评估测试(chronic obstructive pulmonary disease assessment test, CAT)评分、C反应蛋白(C-reactive protein, CRP)、降钙素原(procalcitonin, PCT)、白细胞(WBC)计数、贝克抑郁和焦虑量表评分, 心理身体紧张松弛测试量表(PSTR)评分均较高(P<0.05)。结论疲劳与中度稳定期慢阻肺患者营养、生活质量、炎症、精神情绪有关,是建立慢阻肺患者多维度疲劳测量的重要部分。

关键词: 肺疾病, 慢性阻塞性, 疲劳, 多维度指标

Abstract:

Objective To study the relationship between fatigue and the indexes of nutritional, quality-of-life, inflammatory, and mental & emotional in patients with stable moderate chronic obstructive pulmonary disease (COPD). Methods In this prospective study, 30 patients(fatigue group) and 26 patients (non-fatigue group), who were in stable moderate COPD, were randomly enrolled according to the definition of general fatigue. The aiming was to compare the baseline data, the indexes of nutritional, quality-of-life, inflammatory, and mental & emotional. Results There was no significant difference in age, gender, smoking index between the two groups (all P>0.05). The indexes of albumin, hemoglobin, body mass, percent predicte forced expiratory volume in one second (FEV1)%, and 6-minute walk distance (6MWD) in the fatigue group were significantly lower than those in the non-fatigue group (all P<0.05). COPD Assessment Test (CAT) score, C-reactive protein (CRP), procalcitonin (PCT), white blood cell (WBC), Beck Anxiety Inventory (BAI), and Physical and mental tension relaxation test (PSTRT) were found to be higher in the fatigue group (all P<0.05). Conclusion Fatigue closely associated with the indexes of nutritional, quality-of-life, inflammatory, and mental & emotional in patients with stable moderate COPD, which is an important part of establishing multi-dimensional fatigue measurement for COPD patients.

Key words: pulmonary disease, chronic obstructive, fatigue, multi dimensional indicators

中图分类号:

R563.9

王雪峰. 中度稳定期慢性阻塞性肺疾病疲劳与多维度指标的关系[J]. 临床荟萃, 2022, 37(8): 704-707.

Wang Xuefeng. Clinical correlation between fatigue and multi-dimensional indexes in patients with stable moderate chronic obstructive pulmonary disease[J]. Clinical Focus, 2022, 37(8): 704-707.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2022.08.005

https://huicui.hebmu.edu.cn/CN/Y2022/V37/I8/704

图/表 5

表1 一般资料

组别	例数	年龄 ( $x -$ ±s,岁)	男性 [例(%)]	吸烟指数
疲劳组	30	68.23±6.64	22(73.3)	409±32
非疲劳组	26	68.73±6.47	18(69.2)	402±26
统计值		$t$ =0.283	χ²=0.002	$t$ =0.835
$P$ 值		0.778	0.966	0.408

表1 一般资料

组别	例数	年龄 ( $x -$ ±s,岁)	男性 [例(%)]	吸烟指数
疲劳组	30	68.23±6.64	22(73.3)	409±32
非疲劳组	26	68.73±6.47	18(69.2)	402±26
统计值		$t$ =0.283	χ²=0.002	$t$ =0.835
$P$ 值		0.778	0.966	0.408

表2 两组营养指标比较($\bar{x}±s$)

组别	例数	白蛋白 (g/L)	血红蛋白 (g/L)	体重指数 (kg/m²)
疲劳组	30	27.31±4.45	86.37±12.52	15.88±1.88
非疲劳组	26	30.86±3.65	94.88±14.39	17.66±1.99
$t$ 值		3.233	2.369	3.439
$P$ 值		0.002	0.021	0.001

表2 两组营养指标比较($\bar{x}±s$)

组别	例数	白蛋白 (g/L)	血红蛋白 (g/L)	体重指数 (kg/m²)
疲劳组	30	27.31±4.45	86.37±12.52	15.88±1.88
非疲劳组	26	30.86±3.65	94.88±14.39	17.66±1.99
$t$ 值		3.233	2.369	3.439
$P$ 值		0.002	0.021	0.001

表3 两组生活质量指标比较($\bar{x}±s$)

组别	例数	FEV1% (%)	6MWD (米)	CAT评分 (分)
疲劳组	30	58.73±3.29	324.17±33.91	14.26±2.09
非疲劳组	26	63.77±3.55	352.75±31.08	11.55±1.81
$t$ 值		5.51	3.268	5.14
$P$ 值		0.000	0.002	0.000

表3 两组生活质量指标比较($\bar{x}±s$)

组别	例数	FEV1% (%)	6MWD (米)	CAT评分 (分)
疲劳组	30	58.73±3.29	324.17±33.91	14.26±2.09
非疲劳组	26	63.77±3.55	352.75±31.08	11.55±1.81
$t$ 值		5.51	3.268	5.14
$P$ 值		0.000	0.002	0.000

表4 两组炎症指标比较($\bar{x}±s$)

组别	例数	WBC计数 (×10⁹/L)	PCT (ng/ml)	CRP (mg/L)
疲劳组	30	9.13±2.43	0.39±0.29	26.26±23.7
非疲劳组	26	7.81±1.89	0.19±0.24	14.68±13.27
$t$ 值		2.246	2.895	2.208
$P$ 值		0.029	0.005	0.031

表4 两组炎症指标比较($\bar{x}±s$)

组别	例数	WBC计数 (×10⁹/L)	PCT (ng/ml)	CRP (mg/L)
疲劳组	30	9.13±2.43	0.39±0.29	26.26±23.7
非疲劳组	26	7.81±1.89	0.19±0.24	14.68±13.27
$t$ 值		2.246	2.895	2.208
$P$ 值		0.029	0.005	0.031

表5 两组精神情绪指标比较($\bar{x}±s$,分)

组别	例数	贝克抑郁量表评分	贝克焦虑量表评分	PSTR量表评分
疲劳组	30	6.30±1.32	6.53±1.14	74.23±13.32
非疲劳组	26	5.23±0.71	5.23±0.71	65.69±13.91
$t$ 值		3.701	5.048	2.345
$P$ 值		0.001	0.000	0.023

表5 两组精神情绪指标比较($\bar{x}±s$,分)

组别	例数	贝克抑郁量表评分	贝克焦虑量表评分	PSTR量表评分
疲劳组	30	6.30±1.32	6.53±1.14	74.23±13.32
非疲劳组	26	5.23±0.71	5.23±0.71	65.69±13.91
$t$ 值		3.701	5.048	2.345
$P$ 值		0.001	0.000	0.023

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