关键词: 肺炎；因素分析, , 统计学；革兰氏阴性菌感染；碳青霉烯；抗药性, 细菌

Abstract: Objective  To explore the risk factors and its related prognostic factors of the pneumonia caused by Carbapenemresistant  gramnegative bacteria(CRGNB).Methods  We retrospectively analyzed the clinical materials of patients diagnosed by gramnegative bacteria  pneumonia in 2016. According to the sputum or bronchoalveolar lavage fluid(BALF) culture results,  patients were divided into CRGNB group (n=114) and nCRGNB group (n=112). We further divided CRGNB group into survived (n=88) and died (n=26) in terms of patients'  30 day prognosis.We conducted the statistical analysis using univariate analysis and multivariate analysis to identify independent risk factors for CRGNB and associated mortability in pneumonia patients. Results  Univariate analysis revealed that eleven factors were associated with the pneumoniae caused by CRGNB,  including ICU stay,  recent history of surgery,  bedridden,  fever,  conscious disturbance,  carbapenem antibiotics application in past 90 days,  respiratory failure,  shock,  invasive manipulation,  ABA and SMA infection,  hospital acquired. ICU stay,  coronary heart disease,  diabetes mellitus,  renal failure,  respiratory failure,  shock,  retention catheterization,  deep vein catheterization and mechanical ventilation were associated with the mortality of CRGNB pneumonia. Multivariate analysis showed that Carbapenem  antibiotics application in past 90 days,  mechanical ventilation,  ABA infection and hospital acquired is independent risk factor of CRGNB. Furthermore,  shock,  deep vein catheterization,  diabetes mellitus and coronary heart diseases were independently associated with mortality of CRGNB pneumonia. Conclusion  Carbapenem  antibiotics application in past 90 days,  mechanical ventilation,  ABA infection and hospital acquired is independent risk factor of CRGNB. Furthermore,  shock,  deep vein catheterization,  diabetes mellitus and coronary heart diseases were independently associated with mortality of CRGNB pneumonia.

Key words: pneumoniae; , factor analysis, statistical, gramnegative bacterial infections, carbapenem; , drug resistance, , bacterial