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认知行为疗法治疗慢性失眠临床疗效的系统评价和Meta分析

  

  1. 河南中医药大学第一附属医院  脑病科,河南 郑州  450000
  • 出版日期:2019-05-20 发布日期:2019-06-28
  • 通讯作者: 赵敏,Email:byts2011@126.com
  • 基金资助:
    河南省中医药科学研究专项--慢性失眠中医药诊疗方案优化和评价研究(2018JD2X111)

Systematic review and metaanalysis:clinical effect of cognitive behavioral therapy on chronic insomnia

  1. Department of Encephalopathy, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
  • Online:2019-05-20 Published:2019-06-28
  • Contact: Corresponding author: Zhao Min, Email: byts1969@126.com

摘要: 目的  系统评价认知行为疗法治疗慢性失眠的临床疗效。方法  计算机检索中文文献来源:中国知网数据库、重庆维普中文数据库、万方数据库、中国生物医学文献数据库、外文文献检索的数据库包括:PubMed、The Cochrane Library。查找认知行为疗法治疗慢性失眠的随机对照试验(RCT),自建库至2018年11月8日时限内文献均纳入检索范围。并对纳入文献的参考文献进行手工检索。按纳入排除标准由两人独立进行RCT的筛选、资料提取和质量评价后,采用RevMan5.3软件进行Meta分析。结果  共纳入17项研究,涉及1 131例慢性失眠患者,试验的方法学质量部分偏低。Meta分析结果显示:试验组与对照组比较,睡眠潜伏期MD=-8.01, 95%CI为(-10.96,-5.06);觉醒次数MD=-0.43, 95%CI为 (-0.70,-0.16);睡眠总时间MD=39.51,95%CI为 (27.09, 51.93), 睡眠效率MD=7.85,95%CI为 (1.90, 13.80);匹兹堡睡眠质量指数MD=-2.44,95%CI为 (-3.32, -1.56);治疗有效率OR=3.18,95%CI为 (1.81, 5.61);失眠严重程度指数MD=-1.30,95%CI为 (-2.06,-0.54)。结论  目前临床证据表明,认知行为治疗慢性失眠临床疗效可靠。

关键词: 认知疗法;睡眠障碍, Meta分析

Abstract: Objective  To systematically evaluate the clinical effect of cognitive behavioral therapy on chronic insomnia. Methods  Chinese literature sources were explored for computer retrieval: CNKI,Chongqing Weipu Chinese Database, Wanfang Database, Chinese Biomedical Literature Database, and foreign literature retrieval databases include PubMed and The Cochrane Library. The randomized controlled trials(RCTs) of cognitive behavioral therapy for chronic insomnia were searched, and all literatures were included in the retrieval scope within the selfbuilt database until the time limit of November 8, 2018. References included in the literature were searched manually. Metaanalysis was conducted by RevMan 5.3 software after RCT screening, data extraction and quality evaluation independently by two individuals according to inclusion and exclusion criteria. Results  A total of 17 studies were included, involving 1 131 patients with chronic insomnia, and the methodological quality of the trial was partially low.  Compared with the control group, the sleep latency MD=-8.01, 95%CI was (-10.96,-5.06); the number of awakenings MD=-0.43, and the 95%CI was(-0.70,-0.16); the total sleep time MD=39.51, 95%CI (27.09, 51.93); the sleep efficiency MD=7.85, 95%CI (1.90, 13.80);  and Pittsburgh sleep quality index MD=-2.44, 95%CI (-3.32,-1.56);  the treatment efficiency OR=3.18, 95%CI (1.81, 5.61;  and the insomnia severity index MD=-1.30, 95%CI (-2.06, -0.54). Conclusion  According to current clinical evidence, cognitive behavioral therapy for  chronic insomnia is clinically reliable.

Key words: cognitive , therapy; , maintenance disorders; metaanalysis