TNF-α-308基因多态性与胃癌易感相关性的meta分析

doi:10.3969/j.issn.1004-583X.2023.09.002

摘要/Abstract

摘要：

目的分析肿瘤坏死因子-α(TNF-α)启动子308位点多态性与胃癌易感性的关系。方法检索Pubmed、Embase、Web of Science、Cochrane library、万方数据和中国知网数据库中有关TNF-α-308基因多态性与胃癌发病风险的病例对照研究,时间截至2022年6月。由2位研究者独立进行文献筛选、提取数据及评价偏倚风险,通过Stata16.0软件进行Meta分析。结果纳入41项病例-对照研究,共7528例胃癌患者和10924例对照。Meta分析结果显示:等位,杂合和显性模型TNF-α-308位点多态性与增加胃癌患病风险相关[A vs G: $O R$ =1.21,95% $C I$ (1.01, 1.44), $P$ =0.039; AG vs GG: $O R$ =1.26, 95% $C I$ (1.07, 1.49), $P$ =0.392; AA+AG vs GG: $O R$ =1.22, 95% $C I$ (1.00, 1.47), $P$ =0.046]。5项由幽门螺旋杆菌感染引发胃癌的研究结果显示,TNF-α-308位点多态性与幽门螺旋杆菌感染的胃癌易感无关。亚组分析显示, 亚洲地区[A vs G: $O R$ =1.29, 95% $C I$ (1.04, 1.61), $P$ =0.022; AG vs GG: $O R$ =1.35, 95% $C I$ (1.06, 1.71), $P$ =0.014; AA+AG vs GG: $O R$ =1.36, 95% $C I$ (1.07, 1.73), $P$ =0.013]和非洲所有遗传模型TNF-α-308位点多态性与增加胃癌发病风险相关( $P$ <0.05),美洲和欧洲任何遗传模型下均未显示二者关联;Taqman分型研究中所有遗传模型均显示TNF-α-308多态性与增加胃癌患病风险相关( $P$ <0.05)。结论亚洲地区TNF-α-308位点多态性可能与增加胃癌易感风险有关;TNF-α-308位点多态性与幽门螺旋杆菌感染的胃癌易感无关。

关键词: 胃肿瘤, TNF-α-308, 幽门螺旋杆菌感染, 单核苷酸多态性, Meta分析

Abstract:

Objective To investigate the correlation between tumor necrosis factor-α (TNF-α) promoter 308 locus (TNF-α-308) gene polymorphism and gastric cancer susceptibility. Methods Case-control studies on TNF-α-308 gene polymorphism and the susceptibility to gastric cancer published before June 2022 were searched in Pubmed, Embase, Web of Science, Cochrane library, Wanfang and China National Knowledge Infrastructure (CNKI). Literature screening, data extraction and evaluation of risk of bias were performed independently by 2 investigators. Meta-analysis was performed via Stata 16.0 software. Results A total of 41 case-control studies were included, involving 7528 gastric cancer patients and 10924 controls. Meta-analysis showed that in allelic, heterozygous and dominant models, TNF-α-308 gene polymorphisms were significantly correlated with with an increased risk of gastric cancer (A vs G: $O R$ =1.21, 95% $C I$ : 1.01-1.44, $P$ =0.039; AG vs GG: $O R$ =1.26, 95% $C I$ : 1.07-1.49, $P$ =0.392; AA+AG vs GG: $O R$ =1.22, 95% $C I$ : 1.00-1.47, $P$ =0.046). Five studies of gastric cancer caused by Helicobacter pylori infection showed that TNF-α-308 gene polymorphisms were not correlated with susceptibility to gastric cancer. Subgroup analyses showed that all genetic models in Asian areas (A vs G: $O R$ =1.29, 95% $C I$ : 1.04,1.61, $P$ =0.022; AG vs GG: $O R$ =1.35, 95% $C I$ : 1.06,1.71, $P$ =0.014; AA+AG vs GG: $O R$ =1.36, 95% $C I$ : 1.07,1.73, $P$ =0.013) and in African areas showed a significant correlation between TNF-α-308 gene polymorphisms and risk of gastric cancer ( $P$ <0.05), which was not correlated in American and European areas. All genetic models in Taqman typing study showed a significant correlation between TNF-α-308 locus gene polymorphisms and risk of gastric cancer ( $P$ <0.05). Conclusion A significant correlation between TNF-α-308 gene polymorphisms and risk of gastric cancer is found in Asian areas. It is not correlated with the susceptibility to gastric cancer caused by Helicobacter pylori infection.

Key words: stomach neoplasms, TNF-α-308, Helicobacter pylori infection, single nucleotide polymorphism, meta-analysis

中图分类号:

R735.2

吕畅, 周利明. TNF-α-308基因多态性与胃癌易感相关性的meta分析[J]. 临床荟萃, 2023, 38(9): 779-787.

Lyu Chang, Zhou Liming. Correlation between the TNF-α-308 gene polymorphism and gastric cancer susceptibility: A meta-analysis[J]. Clinical Focus, 2023, 38(9): 779-787.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2023.09.002

https://huicui.hebmu.edu.cn/CN/Y2023/V38/I9/779

图/表 8

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