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孤立性髓系肉瘤行造血干细胞移植1例并文献复习

  

  1. 1.潍坊医学院 内科学教研室,山东 潍坊 261053;  2.潍坊市人民医院 血液内科, 山东 潍坊 261000
  • 出版日期:2019-06-20 发布日期:2019-08-02
  • 通讯作者: 王宝宏, Email: wfwxzhang@163.com

Literature review of one case of isolated myeloid sarcoma received hematopoietic stem cell transplantation

  1. 1.Department of Internal Medicine, Weifang Medical College,  Weifang 261053, China;
    2.Department of Hematology, Weifang People's Hospital,Weifang  261000,  China
  • Online:2019-06-20 Published:2019-08-02
  • Contact: Corresponding author: Wang Baohong, Email: wfwxzhang@163.com

摘要: 结合文献对1例孤立性髓系肉瘤(IMS)的临床表现、免疫组织化学及治疗预后进行分析,提高对IMS的认识。若IMS发生在罕见部位,大体不呈浅绿色,细胞分化差,又无免疫组织化学时,诊断困难,极易误诊为淋巴瘤、横纹肌肉瘤等,所以确诊IMS必须依据病理及免疫组织化学。IMS有向急性白血病转化进展的高风险,病变位于局部仍需化疗,条件允许应及时行造血干细胞移植,延缓疾病复发,延长生存期及改善预后。

关键词: 肉瘤,  , 髓样, 免疫组织化学, 放射疗法, 造血干细胞移植

Abstract: To enhance the  understanding of isolated myeloid sarcoma, an analysis combined with the review of literatures was conducted on the clinical manifestations, immunohistochemistry, treatment  and prognosis of one case of myeloid sarcoma .Should IMS occur in a rare site with poor differentiation and without immunohistocemistry  or light green appearance,  it would be  easily misdiagnosed as lymphoma,  rhabdomyosarcoma and so on,  which decides the diagnosis based on pathology and immunohistochemistry. There  is a high risk of IMS transforming into acute leukemia.Despite the localized nature of tumor, intensive antileukemia chemotherapy is necessary.Conditions permitting,  hematopoietic stem cell transplantation should be carried out in time to delay disease recurrence,  prolong  the period of survival and improve  prognosis.

Key words: sarcoma, , myeloid, immunohistochemistry, radiotherapy, hematopoietic stem cell transplantation