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3 404例2型糖尿病患者视网膜病变患病率及其相关因素分析

  

  1. 安徽医科大学第三附属医院 内分泌科,安徽 合肥 230000
  • 出版日期:2020-01-20 发布日期:2020-03-18
  • 通讯作者: 刘尚全,Email:52100325@qq.com
  • 基金资助:
    国家自然科学基金资助项目----淫羊霍次苷Ⅱ调控OPG表达及机制研究(30840106)

Prevalence of retinopathy and its related factors in 3 404 patients with type 2 diabetes mellitus

  1. Department of Endocrinology,  the Third Affiliated Hospital of Anhui Medical University,  Hefei  230000,  China
  • Online:2020-01-20 Published:2020-03-18
  • Contact: Corresponding author: Liu Shangquan,Email:52100325@qq.com

摘要: 目的  分析2型糖尿病(T2DM)患者视网膜病变(DR)患病率及其相关因素。方法  对3 404例2型糖尿病住院患者进行回顾性研究,根据眼科会诊结果,将患者分为3组,其中非DR组(A组/NDR组)2 562例,DR非增殖期组(B组/NPDR组)716例,DR增殖期组(C组/PDR组)126例。得出DR的患病率,比较3组患者之间临床资料及临床指标的异同,及其与DR的相关性。结果  2型糖尿病患者DR患病率达24.7%,与甘油三酯(OR=1.110,P=0.000)、糖化血红蛋白(HbA1c)(OR=1.087,P=0.000)、血尿酸(OR=1.003,P=0.000)、病程(OR=1.002,P=0.000)相关。结论  2型糖尿病患者DR患病率为24.7%,高血脂、高血糖、高尿酸血症、病程长为DR的独立危险因素。早期发现糖尿病、早期治疗糖尿病、积极控制血糖血脂血尿酸,对于减少DR的发生及延缓DR的发展意义重大。

关键词: 糖尿病, 2型, 糖尿病视网膜病变, 因素分析,  , 统计学

Abstract: Objective  To analyze the incidence and related factors of diabetic retinopathy(DR) in patients with type 2 diabetes mellitus(T2DM).Methods  A total of  3 404  inpatients with T2DM were studied retrospectively. According to the results of ophthalmic consultation,  the patients were divided into three groups,  including 2 562 cases ofnonDR group (group A/NDR),  716 cases of  non proliferative DR group (group B/NPDR),  and 126 cases of  proliferative DR group (group C/PDR).The incidence of DR was obtained,  then the differences and similarities in clinical data and clinical indicators among three groups were compared,  as well as  the  prevalence of DR.Results  The incidence rate of  DR  in T2DM patients was 24.7%,  which was correlated associated with triglyceride (OR=1.110,  P=0.000),  glycosylated hemoglobin (HbA1c) (OR=1.087,  P=0.000),  serum uric acid (OR=1.003,  P=0.000),  course of disease (OR=1.002,  P=0.000).Conclusion  The incidence rate of  DR in T2DM  patients was 24.7%, and hyperlipidemia,  hyperglycemia,  hyperuricemia,  long course of disease were independent risk factors for DR.Early detection and treatment of diabetes, active control of blood glucose, lipids and uric acid are of great significance to reduce the occurrence of DR and delay the development of DR.

Key words: diabetes,  , type 2;diabetic retinopathy, factors analysis, statistical