关键词: 前体细胞淋巴母细胞白血病淋巴瘤, ARID5B, rs10821936, 基因多态性, Meta分析, 系统评价

Abstract: Objective  To explore the association between ARID5B gene rs10821936 polymorphism and the risk of childhood acute lymphoblastic leukemia (ALL).Methods  The cochrane  library, PubMed, EMCC, OVID，CNKI, VIP and Wanfang digital knowledge service platform were searched for relevant articles published in English and Chinese up to March 2019.Two researchers independently extracted data and assessed the literature.Literature bias risk assessment was also conducted.RevMan5.3 and Stata 12.0 software were used to analyze the association between gene polymorphism and  the risk of childhood ALL with risk allele frequency,  recessive,  dominant,  codominant and allele models,  respectively.Results  A total of 19 studies in 15 references were included in the metaanalysis,  including 11 542 cases in  case group and 30 205 cases in  control group. Metaanalysis results of all models showed that risk allele frequency (OR=1.77,  95%CI:1.701.85),  recessive (OR=1.94,  95%CI:1.612.23),  dominant (OR=1.92,  95%CI: 1.752.12),  codominant (OR=2.65,  95%CI:2.313.03),  and allele model (OR=1.67,  95%CI:1.491.87) were associated withthe risk of childhood ALL. According to the group analysis by race,  the dominance model (CC+TC vs TT) of Chinese population (OR=2.16,  95%CI:0.935.00) was not correlated with the susceptibility of childhood ALL,  while the subgroup analysis of other gene models was still correlated with the increased risk of ALL in children.Conclusion  ARID5B gene SNPs rsl0821936  may be associated with an increased risk of childhood ALL, but the susceptibility correlation with ALL in Chinese children remains further study.

Key words: precursor cell lymphoblastic leukemialymphoma, ARID5B, rs10821936 polymorphism, genetic polymorphism, metaanalysis, systematic review